Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2022; 14(10): 2077-2084
Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.2077
Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor: A case report and review of literature
Kengo Fujita, Ayaka Okubo, Toshitsugu Nakamura, Nobumichi Takeuchi
Kengo Fujita, Ayaka Okubo, Nobumichi Takeuchi, Department of Medical Oncology, Ina Central Hospital, Nagano 396-8555, Japan
Toshitsugu Nakamura, Department of Diagnostic Pathology, Ina Central Hospital, Nagano 396-8555, Japan
Author contributions: Fujita K and Okubo A collected and interpreted clinical data, reviewed the literatures, and drafted a manuscript; Nakamura T was involved in pathological diagnosis and revised the manuscript critically for intellectual content; Takeuchi N was the patient’s primary oncologist and revised the manuscript critically for intellectual content; and all authors critically revised the report, commented on drafts of the manuscript, and approved the final report.
Informed consent statement: Informed written consent was obtained from the patient’s family members for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nobumichi Takeuchi, MD, PhD, Director, Doctor, Department of Medical Oncology, Ina Central Hospital, 1313-1 Ina, Nagano 396-8555, Japan. ntakeuti@inahp.jp
Received: May 21, 2022
Peer-review started: May 21, 2022
First decision: June 23, 2022
Revised: July 8, 2022
Accepted: August 21, 2022
Article in press: August 21, 2022
Published online: October 15, 2022
Processing time: 146 Days and 8.3 Hours
Core Tip

Core Tip: Disseminated carcinomatosis of the bone marrow (DCBM) is a rare manifestation of recurrence of a treated cancer, mainly gastric cancer. We reported a case of DCBM 8 years after curative surgery for T1 gastric cancer. Immunostaining for granulocyte colony-stimulating factor (G-CSF) receptor was diffusely positive in the relapsed lesions, but it was negative in the primary lesion. The administration of G-CSF during treatment for Ewing sarcoma within 2 years before the relapse could have been the trigger for the gastric cancer recurrence. G-CSF administration in patients with history of cancer could be a risk factor for recurrence.