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Davis HW, Kaynak A, Vallabhapurapu SD, Qi X. Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer. World J Gastrointest Oncol 2021; 13(6): 550-559 [PMID: 34163572 DOI: 10.4251/wjgo.v13.i6.550]
World J Gastrointest Oncol. Jun 15, 2021; 13(6): 550-559 Published online Jun 15, 2021. doi: 10.4251/wjgo.v13.i6.550
Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer
Harold W Davis, Ahmet Kaynak, Subrahmanya D Vallabhapurapu, Xiaoyang Qi
Harold W Davis, Ahmet Kaynak, Subrahmanya D Vallabhapurapu, Xiaoyang Qi, Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Brain Tumor Center at UC Neuroscience Institute, Cincinnati, OH 45267, United States
Ahmet Kaynak, Xiaoyang Qi, Department of Biomedical Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, United States
Author contributions: Davis HW and Qi X conceptualized the review; Kaynak A helped generate the figures; all authors made major contributions to the review’s literature search and contributed to drafting the manuscript; all authors contributed to some or all of our laboratory’s original studies discussed in this review; all authors provided critical review and approved the final manuscript before submission.
Supported byPancreatic Cancer Action Network Translational Research Grant, No. 20-65-QIXI; Give Hope Foundation, National Institutes of Health, No. R01CA158372 and No. R21NS095047; and CCTST Pilot Collaborative Studies, Bearcats Against Cancer, and Hematology-Oncology Programmatic Support from University of Cincinnati College of Medicine (to Qi X).
Conflict-of-interest statement: Qi X is listed as an inventor on the patent for SapC-DOPS technology that is the subject of this review. Consistent with current Cincinnati Children’s Hospital Medical Center policies, the development and commercialization of this technology has been licensed to Bexion Pharmaceuticals, LLC, in which Qi X, holds a minor (< 3%) equity interest.
Corresponding author: Xiaoyang Qi, PhD, Professor, Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Brain Tumor Center at UC Neuroscience Institute, 3512 Eden Avenue, Cincinnati, OH 45267, United States. xiaoyang.qi@uc.edu
Received: January 29, 2021 Peer-review started: January 29, 2021 First decision: April 6, 2021 Revised: April 13, 2021 Accepted: May 10, 2021 Article in press: May 10, 2021 Published online: June 15, 2021 Processing time: 128 Days and 13.4 Hours
Core Tip
Core Tip: This review presents the mechanisms and efficacy of saposin C-dioleoylphosphatidylserine (SapC-DOPS), a novel phosphatidylserine (PS) biomarker-targeted nanodrug, alone and in combination with other treatment modalities for the treatment of pancreatic ductal adenocarcinoma (PDAC) tumors. Our results indicate that SapC-DOPS preferentially targets cells with high surface PS which are primarily in the G2/M phase of the cell cycle. Other treatment modalities such as Gemcitabine, Abraxane and radiation target G1 phase cells that have low surface PS. Combination of SapC-DOPS and Gemcitabine/Abraxane or radiation significantly inhibits tumor growth of orthotopic PDAC tumors in vivo and increases survival compared to individual treatments.
