©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2021; 13(5): 332-350
Published online May 15, 2021. doi: 10.4251/wjgo.v13.i5.332
Published online May 15, 2021. doi: 10.4251/wjgo.v13.i5.332
Liquid biopsy in cholangiocarcinoma: Current status and future perspectives
Gianluca Rompianesi, Roberto Montalti, Roberto Troisi, Hepato-Bilio-Pancreatic, Minimally Invasive and Robotic Surgery Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Napoli 80131, Italy
Marcello Di Martino, Hepato-Bilio-Pancreatic Surgery Unit, Department of General and Digestive Surgery, Hospital Universitario La Princesa, Madrid 28006, Spain
Alex Gordon-Weeks, Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX3 9DU, United Kingdom
Author contributions: Rompianesi G and Di Martino M wrote the paper; Gordon-Weeks A, Montalti R and Troisi R reviewed and edited the manuscript.
Conflict-of-interest statement: All Authors have no conflicts of interest to declare.
Corresponding author: Gianluca Rompianesi, MD, PhD, FEBS, Assistant Professor, Surgeon, Hepato-Bilio-Pancreatic, Minimally Invasive and Robotic Surgery Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, via S. Pansini 5, Napoli 80131, Italy. gianlucarompianesi@gmail.com
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: March 1, 2021
Revised: March 2, 2021
Accepted: March 31, 2021
Article in press: March 31, 2021
Published online: May 15, 2021
Processing time: 99 Days and 15.8 Hours
Peer-review started: January 27, 2021
First decision: March 1, 2021
Revised: March 2, 2021
Accepted: March 31, 2021
Article in press: March 31, 2021
Published online: May 15, 2021
Processing time: 99 Days and 15.8 Hours
Core Tip
Core Tip: Liquid biopsy allows to access tumoral components and genetic material from fluid samples. In patients affected by cholangiocarcinoma could play a major role as minimally invasive screening and diagnostic biomarker, prognostic tool and therapeutic monitoring target, but its role in the clinical practice is still marginal and further research is necessary.