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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2021; 13(12): 2129-2148
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2129
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2129
BRAFV600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs
Jie Zhi, Hui-Cong Wang, Bo Feng, Yi-Tao Jia, Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Xiao-Jing Jia, Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang 050051, Hebei Province, China
Jing Yan, Department of Oncology, Puyang People’s Hospital, Puyang 457000, Henan Province, China
Han-Ying Xing, Clinical Medical Research Center, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Author contributions: Jia YT made substantial contributions to the conception and design of the study; Zhi J searched and reviewed published articles and wrote the manuscript; Jia XJ and Yan J collected patient data and prepared the tables; Zhi J, Jia XJ, Yan J and Wang HC performed the relevant experiments in the manuscript, statistically analyzed the data, and prepared the figures; Feng B and Xing HY critically reviewed the article and made revisions to the manuscript; all authors approved the final version.
Institutional review board statement: The study was reviewed and approved by the Hebei General Hospital Institutional Review Board (approval No. 202134).
Conflict-of-interest statement: The authors report no conflicts of interest for this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Tao Jia, MD, Professor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China.
Received: July 13, 2021
Peer-review started: July 13, 2021
First decision: August 9, 2021
Revised: August 18, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: December 15, 2021
Processing time: 154 Days and 7.1 Hours
Peer-review started: July 13, 2021
First decision: August 9, 2021
Revised: August 18, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: December 15, 2021
Processing time: 154 Days and 7.1 Hours
Core Tip
Core Tip: This study revealed that BRAFV600E mutant colorectal cancer (CRC) cells could lead to more angiogenesis and lymphoangiogenesis in the microenvironment by releasing exosomal long noncoding RNAs, inducing the formation of an immunosuppressive microenvironment. Our findings provide a hypothesis for finding new therapeutic strategies for BRAFV600E mutant CRC.