Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2021; 13(12): 1981-1996
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.1981
Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
Lin-Xian Zhao, Kai Zhang, Bing-Bing Shen, Jian-Nan Li
Lin-Xian Zhao, Kai Zhang, Jian-Nan Li, Department of General Surgery, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Bing-Bing Shen, Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Zhao LX wrote the paper; Zhang K and Shen BB collected the data; Li JN designed the review and revised the paper; Zhao LX, Zhang K, Shen BB, and Li JN performed the approval of final revision; Zhao LX and Zhang K contributed equally to this work.
Supported by Science and Technology Development Project of Jilin Province, No. 3D5197434429; and Youth Program of the National Natural Science Foundation of China, No. 3A4205367429.
Conflict-of-interest statement: The authors declare that there is no conflict of interest for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Nan Li, MD, PhD, Assistant Professor, Department of General Surgery, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, Jilin Province, China. jnli@ciac.ac.cn
Received: April 29, 2021
Peer-review started: April 29, 2021
First decision: June 5, 2021
Revised: August 15, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: December 15, 2021
Processing time: 229 Days and 21.6 Hours
Core Tip

Core Tip: Mesenchymal stem cells (MSCs) have shown potential for anti-cancer therapy. As an important content of MSCs, MSC-derived exosomes are attracting more and more researchers for anti-cancer studies. We herein summarize the effect of MSC-derived exosomes on gastrointestinal malignancies and discuss their therapeutic potential.