Li YD, He KX, Zhu WF. Correlation between invasive microbiota in margin-surrounding mucosa and anastomotic healing in patients with colorectal cancer. World J Gastrointest Oncol 2019; 11(9): 717-728 [PMID: 31558976 DOI: 10.4251/wjgo.v11.i9.717]
Corresponding Author of This Article
Wei-Fang Zhu, MD, Assistant Professor, Division of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. wfzhu@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
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Li YD, He KX, Zhu WF. Correlation between invasive microbiota in margin-surrounding mucosa and anastomotic healing in patients with colorectal cancer. World J Gastrointest Oncol 2019; 11(9): 717-728 [PMID: 31558976 DOI: 10.4251/wjgo.v11.i9.717]
World J Gastrointest Oncol. Sep 15, 2019; 11(9): 717-728 Published online Sep 15, 2019. doi: 10.4251/wjgo.v11.i9.717
Correlation between invasive microbiota in margin-surrounding mucosa and anastomotic healing in patients with colorectal cancer
Yan-Dong Li, Kang-Xin He, Wei-Fang Zhu
Yan-Dong Li, Division of Colon and Rectal Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Kang-Xin He, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Wei-Fang Zhu, Division of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Li YD, He KX, and Zhu WF contributed equally to this work; He KX and Zhu WF designed the research; Li YD and He KX performed the research; Li YD and He KX analyzed the data; and Li YD, He KX, and Zhu WF wrote the paper.
Supported byZhejiang Administration of Traditional Chinese Medicine, No. 2017ZA082.
Institutional review board statement: The study protocol was reviewed and approved by the First Affiliated Hospital, Zhejiang University School of Medicine Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Data sharing statement: Data from this manuscript will be available upon request.
Corresponding author: Wei-Fang Zhu, MD, Assistant Professor, Division of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. wfzhu@163.com
Telephone: +86-571-87236559 Fax: +86-571-87236559
Received: July 23, 2019 Peer-review started: July 23, 2019 First decision: August 27, 2019 Revised: August 30, 2019 Accepted: September 4, 2019 Article in press: September 4, 2019 Published online: September 15, 2019 Processing time: 51 Days and 2.1 Hours
Core Tip
Core tip: This study investigated the correlation between microbiota in mucosa tissues adjacent to surgical margin and anastomotic healing status. Bacterial community structure significantly varied in the impaired-healing group compared with the well-healing group. The current study was the first to demonstrate that six bacterial species were associated with the anastomotic healing in colorectal cancer (CRC) patients. Notably, Alistipes shahii, Dialister pneumosintes, and Corynebacterium suicordis in combination with age improved the accuracy for predicting the healing status of anastomoses. Thus, the three species could be used as the supplementary factors in predicting the healing status of anastomoses in CRC patients after radical resection of CRC.
