Retrospective Cohort Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2019; 11(4): 295-309
Published online Apr 15, 2019. doi: 10.4251/wjgo.v11.i4.295
Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy
Chloé Serayssol, Charlotte Maulat, Florence Breibach, Fatima-Zohra Mokrane, Janick Selves, Rosine Guimbaud, Philippe Otal, Bertrand Suc, Emilie Berard, Fabrice Muscari
Chloé Serayssol, Charlotte Maulat, Bertrand Suc, Fabrice Muscari, Department of Digestive Surgery and Liver Transplantation, Toulouse-Rangueil University Hospital, Toulouse 31059, France
Florence Breibach, Janick Selves, Department of Pathology, Toulouse University Hospital, Toulouse 31059, France
Fatima-Zohra Mokrane, Philippe Otal, Department of Radiology, Toulouse-Rangueil University Hospital, Toulouse 31059, France
Rosine Guimbaud, Department of Oncology, Toulouse-Rangueil University Hospital, Toulouse 31059, France
Emilie Berard, The Toulouse Research Methodology Support Unit, Toulouse University Hospital, Toulouse 31000, France
Author contributions: Serayssol C, Maulat C, Breibach F, Berard E and Muscari F performed the research and wrote the paper; Mokrane FZ, Selves J, Guimbaud R, Otal P and Suc B provided critical revision of the manuscript for important intellectual content.
Institutional review board statement: This study was reviewed and approved by the Toulouse University Hospital Review Board.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Charlotte Maulat, Academic Fellow, Department of Digestive Surgery and Liver Transplantation, Toulouse-Rangueil University Hospital, CHU Rangueil, 1 avenue J Poulhès, Toulouse 31059, France. charlotte.maulat@gmail.com
Telephone: +33-561322741 Fax: +33-561322936
Received: October 2, 2018
Peer-review started: October 2, 2018
First decision: October 25, 2018
Revised: November 27, 2018
Accepted: December 31, 2018
Article in press: January 1, 2019
Published online: April 15, 2019
Processing time: 196 Days and 12.9 Hours
Core Tip

Core tip: In this study, we analyzed the histological responses of colorectal liver metastasis from 74 responders and 76 non-responders after neoadjuvant chemotherapy. We identified that the absence of a radiological response and extended neoadjuvant chemotherapy, comprising more than seven treatment sessions, are the two most pertinent predictive factors of non-histological response. This study also confirmed that the histological response of colorectal liver metastases after neoadjuvant chemotherapy has an influence on survival and, hence, warrants consideration. However, this influence on overall survival was lacking in cases of particularly aggressive disease that revealed microscopic vascular invasion in histological analyses.