Archibugi L, Testoni SGG, Redegalli M, Petrone MC, Reni M, Falconi M, Doglioni C, Capurso G, Arcidiacono PG. New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer. World J Gastrointest Oncol 2019; 11(11): 933-945 [PMID: 31798775 DOI: 10.4251/wjgo.v11.i11.933]
Corresponding Author of This Article
Gabriele Capurso, MD, PhD, Chief Doctor, Pancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy. capurso.gabriele@hsr.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
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Archibugi L, Testoni SGG, Redegalli M, Petrone MC, Reni M, Falconi M, Doglioni C, Capurso G, Arcidiacono PG. New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer. World J Gastrointest Oncol 2019; 11(11): 933-945 [PMID: 31798775 DOI: 10.4251/wjgo.v11.i11.933]
World J Gastrointest Oncol. Nov 15, 2019; 11(11): 933-945 Published online Nov 15, 2019. doi: 10.4251/wjgo.v11.i11.933
New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer
Livia Archibugi, Sabrina Gloria Giulia Testoni, Miriam Redegalli, Maria Chiara Petrone, Michele Reni, Massimo Falconi, Claudio Doglioni, Gabriele Capurso, Paolo Giorgio Arcidiacono
Livia Archibugi, Sabrina Gloria Giulia Testoni, Maria Chiara Petrone, Gabriele Capurso, Paolo Giorgio Arcidiacono, Pancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy
Miriam Redegalli, Claudio Doglioni, Pathology Department, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy
Michele Reni, Department of Medical Oncology, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy
Massimo Falconi, Pancreatic Surgery Department, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy
Author contributions: Archibugi L and Testoni SGG contributed equally to the paper and share first authorship; Archibugi L, Testoni SGG, and Redegalli M performed the literature search and drafted the manuscript; Petrone MC, Doglioni C, Capurso G, and Arcidiacono PG critically revised the manuscript; Capurso G, Reni M, Falconi M, Doglioni C, Petrone MC, and Arcidiacono PG provided scientific guidance; all authors revised and approved the final version of this article.
Supported byAssociazione Italiana Ricerca sul Cancro (AIRC), No. IG 17177
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Corresponding author: Gabriele Capurso, MD, PhD, Chief Doctor, Pancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy. capurso.gabriele@hsr.it
Telephone: +39-02-26436548 Fax: +39-02-26435607
Received: June 15, 2019 Peer-review started: June 19, 2019 First decision: July 31, 2019 Revised: August 1, 2019 Accepted: August 20, 2019 Article in press: August 21, 2019 Published online: November 15, 2019 Processing time: 154 Days and 22.2 Hours
Core Tip
Core tip: Surgical formalin-fixed, paraffin-embedded samples are not representative of all pancreatic ductal adenocarcinoma patients and it has been proven that “pre-resection” fine-needle aspiration smears are a better DNA source. Therefore, endoscopic ultrasound (EUS) is the recommended method for obtaining a tumor’s molecular signature. However, important limitations of EUS-acquired samples are: Intratumoral heterogeneity, total amount of tumoral cells, and lesional-to-non-lesional cell ratio. Furthermore, sample handling and storage conditions might affect the efficiency of DNA and even more RNA extraction. The possibility to obtain sufficient material from EUS to generate patient-derived xenografts or organoids is also a “hot topic”. Thus, optimization and standardization of procedures for EUS-guided biopsy and molecular analyses are essential to allow “precision medicine” for pancreatic ductal adenocarcinoma.
