Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 773-786
Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.773
Study on sex differences and potential clinical value of three-dimensional computerized tomography pelvimetry in rectal cancer patients
Xiao-Cong Zhou, Fei-Yue Ke, Gaurav Dhamija, Hao Chen, Qiang Wang
Xiao-Cong Zhou, Department of Colorectal Surgery, The Dingli Clinical Institute of Wenzhou Medical University (Wenzhou Central Hospital), Wenzhou 325000, Zhejiang Province, China
Fei-Yue Ke, Hao Chen, Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou 325000, Zhejiang Province, China
Gaurav Dhamija, School of International Studies, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Qiang Wang, Department of Radiology, The Dingli Clinical Institute of Wenzhou Medical University (Wenzhou Central Hospital), Wenzhou 325000, Zhejiang Province, China
Co-first authors: Xiao-Cong Zhou and Fei-Yue Ke.
Author contributions: Zhou XC and Ke FY performed the literature review and drafted and revised the manuscript; Dhamija G, Chen H, and Wang Q participated in the study’s design and revised the manuscript for intellectual content; All authors reviewed the manuscript and approved the final manuscript.
Supported by 2021 Zhejiang Province Public Welfare Technology Application Research Funding Project, No. LGC21H160002; Basic Scientific Research Projects in Wenzhou City in 2022, No. Y20220885; and Wenzhou Medical University 2021 Higher Education Teaching Reform Project, No. JG2021167.
Institutional review board statement: The study was reviewed and approved by the Wenzhou Central Hospital Institutional Review Board (Approval No. K2018-01-003).
Informed consent statement: Due to the retrospective cohort study design, the need for informed consent was waived by the Wenzhou Central Hospital Institutional Review Board.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiang Wang, MD, Attending Doctor, Department of Radiology, The Dingli Clinical Institute of Wenzhou Medical University (Wenzhou Central Hospital), No. 252 Baili East Road, Wenzhou 325000, Zhejiang Province, China. franklin1216@sina.com
Received: November 9, 2023
Peer-review started: November 9, 2023
First decision: December 6, 2023
Revised: December 16, 2023
Accepted: January 15, 2024
Article in press: January 15, 2024
Published online: March 15, 2024
Processing time: 123 Days and 23 Hours
ARTICLE HIGHLIGHTS
Research background

This study focused on analyzing the pelvic bone parameters and soft tissue parameters in patients who underwent laparoscopic radical surgery for rectal cancer. The significance of this research lies in understanding the sex disparities in these parameters and their implications for surgical outcomes.

Research motivation

The main motivation behind this research was to address the key problems in accurately measuring the pelvic bone and soft tissue parameters in patients with rectal cancer. By understanding the precise measurements of the pelvic anatomical diameters, angles, ratios, and soft tissue parameters, clinicians can make informed decisions regarding surgical planning and treatment strategies. Solving these measurement challenges can significantly contribute to improving patient outcomes and advancing research in the field of rectal cancer treatment.

Research objectives

The main objectives of this study were to investigate the sex differences in pelvic bone and soft tissue parameters and to determine their potential impact on laparoscopic rectal cancer surgery. By achieving these objectives, this research contributes to the existing knowledge in the field and provides a theoretical basis for addressing related surgical challenges.

Research methods

To achieve the research objectives, a retrospective analysis of clinical, radiological, and pathological data from 218 patients was conducted. Computerized tomography scan data was utilized for 3D pelvic reconstruction, and statistical methods such as paired sample t-tests, Wilcoxon rank-sum tests, and correlation analysis were employed to analyze the parameters.

Research results

The investigation revealed significant sex disparities in 14 pelvic bone parameters and 3 soft tissue parameters. Males exhibited larger measurements in pelvic depth and overall curvature, while females demonstrated wider pelvises and shallower depth. These findings contribute to a better understanding of the anatomical differences between sexes and their implications for laparoscopic rectal cancer surgery.

Research conclusions

This study proposes new insights into the sex-specific anatomical variations in pelvic bone and soft tissue parameters. The findings highlight the importance of considering these differences during surgical planning and decision-making. By recognizing and addressing these disparities, surgeons can optimize surgical outcomes and improve patient care.

Research perspectives

The direction of future research in this field should focus on further exploring the impact of sex disparities in pelvic bone and soft tissue parameters on surgical techniques and patient outcomes. Additionally, investigating the relationship between these parameters and postoperative complications or functional outcomes would provide valuable insights for improving surgical strategies and patient quality of life.