Li Y, Li S, Liu L, Zhang LY, Wu D, Xie TY, Wang XX. Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer. World J Gastrointest Oncol 2023; 15(9): 1605-1615 [PMID: 37746641 DOI: 10.4251/wjgo.v15.i9.1605]
Corresponding Author of This Article
Xin-Xin Wang, MD, PhD, Assistant Professor, Chief Doctor, Department of General Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. 301wxx@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
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Li Y, Li S, Liu L, Zhang LY, Wu D, Xie TY, Wang XX. Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer. World J Gastrointest Oncol 2023; 15(9): 1605-1615 [PMID: 37746641 DOI: 10.4251/wjgo.v15.i9.1605]
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1605-1615 Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1605
Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer
Yang Li, Shuo Li, Lu Liu, Li-Yu Zhang, Di Wu, Tian-Yu Xie, Xin-Xin Wang
Yang Li, Shuo Li, Lu Liu, Li-Yu Zhang, Di Wu, Medical School of Chinese People's Liberation Army, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Tian-Yu Xie, Xin-Xin Wang, Department of General Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Author contributions: Li Y, Li S, and Liu L contributed equally to this work; Wang XX, Li Y, Li S, and Liu L designed the study; Li Y, Li S, and Liu L collected the sample data of the patients; Li S, Liu L, Zhang LY, Wu D, and Xie TY performed the statistical analysis; Li Y wrote the manuscript; all of the authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Chinese PLA General Hospital (No. S2023-065-01).
Informed consent statement: Due to the approval of the Medical Ethics Committee, the informed consent form has been waived.
Conflict-of-interest statement: All of the authors declare no interest in this study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at [301wxx@sina.com]. Participants gave informed consent for data sharing.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Xin-Xin Wang, MD, PhD, Assistant Professor, Chief Doctor, Department of General Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. 301wxx@sina.com
Received: June 14, 2023 Peer-review started: June 14, 2023 First decision: July 7, 2023 Revised: July 15, 2023 Accepted: August 2, 2023 Article in press: August 2, 2023 Published online: September 15, 2023 Processing time: 91 Days and 0.7 Hours
ARTICLE HIGHLIGHTS
Research background
The current prognostic significance of perigastric tumor deposits (TDs) in gastric cancer (GC) remains unclear.
Research motivation
The prognostic value of TDs in GC has not been extensively studied or confirmed. To date, no studies have investigated the prognostic significance of TDs in GC in detail. This study aimed to assess the prognostic value of perigastric TDs and put forward a new and appropriate TNM staging framework involving TDs for primary GC.
Research objectives
This study aimed to assess the prognostic value of perigastric TDs and put forward a new and appropriate TNM staging framework involving TDs for primary GC.
Research methods
We retrospectively analyzed the pathological data of 6672 patients with GC who underwent gastrectomy or surgery for GC with other diseases from January 1, 2012 to December 31, 2017 at the Chinese PLA General Hospital. The patients were divided into TD-positive and TD-negative groups by using the method of propensity score matching. The differences between TD-positive and TD-negative patients were analyzed using binary logistic regression modeling. The Kaplan-Meier method was used to plot survival curves. Multivariate Cox regression modeling and the log-rank test were used to analyze the data.
Research results
With the new GC staging scheme including TDs, the survival curves of patients in the lower grade TNM stage with TDs were closer to those of patients in the higher grade TNM stage without TDs.
Research conclusions
TDs are a poor prognostic factor in patients with primary GC, and a new TNM staging system combining TDs would be suitable for such patients.
Research perspectives
From a clinical point of view, we found deficiencies in the current TNM staging system for GC and conducted this study.
