Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1295
Peer-review started: February 27, 2023
First decision: March 14, 2023
Revised: March 27, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: July 15, 2023
Processing time: 135 Days and 3.3 Hours
Gastric cancer (GC) is a disease with multi-etiology and multi-pathway involvement, and it is characterized by a low 5-year survival rate. NOTCH signaling pathway is also involved in the occurrence and development of GC. Mind bomb 1 (MIB1), an E3 ubiquitin ligase, plays a central role in activating the NOTCH pathway by mediating ubiquitination of NOTCH ligand. However, the effect of MIB1 on GC has not been reported.
To investigate the effect of MIB1 gene on the prognosis of GC.
To investigate the effect of expression and mutation of MIB1 gene on the prognosis of GC, the function of MIB1 in GC and its relationship with immune infiltration.
TCGA database, cBioPortal database, a receiver operating characteristic (ROC) curve, Kaplan-Meier plotter, LinkedOmics database, STRING database, The Gene Ontology enrichment , Kyoto Encyclopedia of Genes and Genomes pathway and TIMER database were used in this study.
The level of MIB1 expression had a certain impact on the survival rate of patients with GC. The prognosis of patients with high MIB1 was worse than that of patients with low MIB1. The increased expression of MIB1 gene was associated with high TNM staging, suggesting that MIB1 may play a role in the development of GC. The expression of MIB1 gene was associated with immune infiltration.
The up-regulation of MIB1 expression was significantly related to the low survival rate and immune infiltration in gastric adenocarcinoma.
MIB1 may be a biomarker for poor prognosis of gastric adenocarcinoma and a potential immunotherapeutic target.