Li WD, Wang HT, Huang YM, Cheng BH, Xiang LJ, Zhou XH, Deng QY, Guo ZG, Yang ZF, Guan ZF, Wang Y. Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis. World J Gastrointest Oncol 2023; 15(5): 787-809 [PMID: 37275445 DOI: 10.4251/wjgo.v15.i5.787]
Corresponding Author of This Article
Yao Wang, MD, Professor, Department of Gastrointestinal Surgery, Zhongshan City People’s Hospital, No. 2 Sunwen East Road, Zhongshan 528403, Guangdong Province, China. wangyao8065@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Li WD, Wang HT, Huang YM, Cheng BH, Xiang LJ, Zhou XH, Deng QY, Guo ZG, Yang ZF, Guan ZF, Wang Y. Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis. World J Gastrointest Oncol 2023; 15(5): 787-809 [PMID: 37275445 DOI: 10.4251/wjgo.v15.i5.787]
Wei-Dong Li, Hai-Tao Wang, Yue-Ming Huang, Bo-Hao Cheng, Li-Jun Xiang, Xin-Hao Zhou, Qing-Yan Deng, Zhi-Gang Guo, Zhi-Feng Yang, Zhi-Fen Guan, Yao Wang, Department of Gastrointestinal Surgery, Zhongshan City People’s Hospital, Zhongshan 528403, Guangdong Province, China
Author contributions: Li WD, Wang HT, and Wang Y designed the study; Huang YM, Cheng BH, Xiang LJ, and Zhou XH collected the data; Deng QY, Guo ZG, Yang ZF, Guan ZF, and Wang Y analyzed the data; Li WD and Wang HT wrote the manuscript; and all authors approved the final manuscript.
Supported byZhongshan Social Public Welfare and Basic Research Project, No. 200421093453685.
Institutional review board statement: The Ethics Committee of Zhongshan City People’s Hospital gave the approval (K2017-182).
Institutional animal care and use committee statement: All experiments were approved by the Animal Care and Use Committee of Zhongshan City People’s Hospital (K2017-182).
Informed consent statement: All participants have also agreed to this investigation by offering their written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All the data used to support the findings of this study are included within the article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Yao Wang, MD, Professor, Department of Gastrointestinal Surgery, Zhongshan City People’s Hospital, No. 2 Sunwen East Road, Zhongshan 528403, Guangdong Province, China. wangyao8065@163.com
Received: November 30, 2022 Peer-review started: November 30, 2022 First decision: December 25, 2022 Revised: January 6, 2023 Accepted: April 7, 2023 Article in press: April 7, 2023 Published online: May 15, 2023 Processing time: 163 Days and 7.8 Hours
ARTICLE HIGHLIGHTS
Research background
Gastric cancer (GC) is a common malignant tumor with high prevalence and mortality. Circular RNA (circRNA) analysis in GSE184882 has indicated that circ_0003356 shows abnormal expression in GC tissues, but the function of circ_0003356 remains unclear in GC.
Research motivation
To seek the prognostic biomarker and therapeutic target for GC.
Research objectives
In order to explore the function and mechanism of circ_0003356 in GC.
Research methods
Quantitative real-time polymerase chain reaction was used to detect expression of circ_0003356. The clinical value of circ_0003356 for GC prognosis was evaluated. The role of circ_0003356 in GC was assessed via in vitro and in vivo experiments. The molecular mechanism of circ_0003356 on miR-668-3p/SOCS3 axis was validated.
Research results
Circ_0003356 expression was markedly decreased in GC tissues and cells, and it was positively associated with survival time of GC patients. Moreover, functional analyses showed that circ_0003356 overexpression inhibited malignant behaviors of GC cells via targeting the miR-668-3p/SOCS3 axis.
Research conclusions
Circ_0003356 is lowly expressed in GC tissues and cells, displaying potential as a prognostic biomarker for GC. Circ_0003356 up-regulation represses the malignancy of GC via targeting the miR-668-3p/SOCS3 axis.
Research perspectives
Other mechanisms of circ_0003356 in GC may be probed in future researches, and its application in treatment of GC will be extended.
