Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2108
Peer-review started: June 25, 2022
First decision: August 30, 2022
Revised: September 13, 2022
Accepted: October 19, 2022
Article in press: October 19, 2022
Published online: November 15, 2022
Processing time: 142 Days and 21.9 Hours
Colorectal cancer is one of the most common malignant tumors in the world. Long noncoding RNAs (lncRNAs) are involved in many normal human physiological functions and pathogenic processes of diseases.
LncRNAs may be used as molecular markers for more accurate prediction of colorectal cancer prognosis. The molecular mechanisms of lncRNAs involved can impact colorectal cancer prognosis and impact the tumor immune microenvironment. Further research into these questions is needed.
To explore the differential expression analysis of mRNAs and lncRNAs in the colorectal cancer and to determine the association between RP5-881L22.5 expression and the tumor immune microenvironment.
We analyzed the immune cell microenvironment through the bioinformatics combined with clinical data and cell experiments to verify the results.
RP5-881 L22.5 expression led to a difference in prognosis, which warrants further research on immunotherapy of advanced tumors with RP5-881 L22.5 as a marker.
RP5-881 L22.5 plays an important role in the pathogenesis of colorectal cancer.
RP5-881 L22.5 may be an important research target for the treatment of colorectal cancer.