Bae JM. Sex as an effect modifier in the association between alcohol intake and gastric cancer risk. World J Gastrointest Oncol 2021; 13(5): 453-461 [PMID: 34040705 DOI: 10.4251/wjgo.v13.i5.453]
Corresponding Author of This Article
Jong-Myon Bae, MD, PhD, Full Professor, Department of Preventive Medicine, Jeju National University College of Medicine, 102 Jejudaehka-ro, Jeju-si 63243, Jeju, South Korea. jmbae@jejunu.ac.kr
Research Domain of This Article
Public, Environmental & Occupational Health
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. May 15, 2021; 13(5): 453-461 Published online May 15, 2021. doi: 10.4251/wjgo.v13.i5.453
Sex as an effect modifier in the association between alcohol intake and gastric cancer risk
Jong-Myon Bae
Jong-Myon Bae, Department of Preventive Medicine, Jeju National University College of Medicine, Jeju-si 63243, Jeju, South Korea
Author contributions: Bae JM performed to select related articles, conduct statistical analysis, and write the paper.
Conflict-of-interest statement: The author declares no conflict of interests and no funding sources for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jong-Myon Bae, MD, PhD, Full Professor, Department of Preventive Medicine, Jeju National University College of Medicine, 102 Jejudaehka-ro, Jeju-si 63243, Jeju, South Korea. jmbae@jejunu.ac.kr
Received: November 27, 2020 Peer-review started: November 27, 2020 First decision: February 14, 2021 Revised: February 22, 2021 Accepted: April 13, 2021 Article in press: April 13, 2021 Published online: May 15, 2021 Processing time: 160 Days and 9.9 Hours
ARTICLE HIGHLIGHTS
Research background
The previous systematic reviews showed a statistically significant association between alcohol intake and gastric cancer risk in men. However, women did not have statistical significance in any of the meta-analyses.
Research motivation
The author hypothesized that alcohol intake’s association with gastric cancer risk may differ between men and women.
Research objectives
The aim was to investigate the suggested hypothesis targeting four previous meta-analyses by performing a meta-epidemiological review.
Research methods
After securing additional cohort studies meeting the selection criteria, updated meta-analysis and subgroup analysis by sex were conducted.
Research results
The subgroup analysis of the 13 men’s cohorts showed that there was statistical significance in Asians, in the group with a high level of adjustment for smoking status, in the group with the adjustment for body mass index, and in more recently published studies. These results were not found in the seven women’s cohorts.
Research conclusions
The present study suggests that alcohol consumption increases the risk of gastric cancer in men.
Research perspectives
It is necessary to re-estimate the follow-up outcomes by stratification for sex to determine whether there is a sex difference in the association between alcohol intake and gastric cancer risk.