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©2012 Baishideng. All rights reserved.
World J Gastrointest Oncol. May 15, 2012; 4(5): 103-108
Published online May 15, 2012. doi: 10.4251/wjgo.v4.i5.103
Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients
Taher Abu Hejleh, Barry R DeYoung, Eric Engelman, Jeremy M Deutsch, Bridget Zimmerman, Thorvardur R Halfdanarson, Daniel J Berg, Kalpaj R Parekh, William R Lynch, Mark D Iannettoni, Sudershan Bhatia, Gerald Clamon
Taher Abu Hejleh, Eric Engelman, Jeremy M Deutsch, Thorvardur R Halfdanarson, Daniel J Berg, Gerald Clamon, Division of Hematology, Oncology and Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, C32 GH, Iowa City, IA 52242-1081, United States
Barry R DeYoung, Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 5238C RCP, Iowa City, IA 52242-1081, United States
Bridget Zimmerman, Department of Biostatistics, College of Public Health, University of Iowa, 200 Hawkins Drive, N377 CPHB, Iowa City, IA 52242-1081, United States
Kalpaj R Parekh, William R Lynch, Mark D Iannettoni, Department of Cardiothoracic Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, SE514 GH, Iowa City, IA 52242-1081, United States
Sudershan Bhatia, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 1624 PFP, Iowa City, IA 52242-1081, United States
Author contributions: Abu Hejleh T performed most of the work, including study design, data collection, analyzing the study results, and writing the manuscript; Engelman E and Deutsch JM participated in designing the study, data collection and editing the manuscript; Halfdanarson TR, Berg DJ and Clamon G participated in the study design, analyzing the results and editing the manuscript; DeYoung BR was involved in the study design, performed the immunohistochemistry stains for HER-2, and edited the manuscript; Zimmerman B addressed the study design, performed the statistical analysis and approved the results included in the final manuscript; Parekh KR, Lynch WR and Iannettoni MD were involved in the study concept and design, performed the surgeries (esophagectomies), edited and approved the final manuscript; Bhatia S participated in the study design, supervised radiation delivery to the esophagus, and edited the final manuscript; all authors approved the final manuscript for publication.
Supported by The Iowa Leukemia and Cancer Research Fund at University of Iowa Hospitals and clinics
Correspondence to: Taher Abu Hejleh, MBBS, Division of Hematology, Oncology and Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Dr. C32 GH, Iowa City, IA52242-1081, United States.
taher-hejleh@uiowa.edu
Telephone: +1-319-6217975 Fax: +1-319-3538383
Received: October 1, 2011
Revised: January 19, 2012
Accepted: March 10, 2012
Published online: May 15, 2012
