Zhao XM, Chen J, Yang L, Luo X, Xu LL, Liu DX, Zhai SL, Li P, Wang XR. Association between IRS-2 G1057D polymorphism and risk of gastric cancer. World J Gastrointest Oncol 2012; 4(1): 9-15 [PMID: 22347534 DOI: 10.4251/wjgo.v4.i1.9]
Corresponding Author of This Article
Xue-Rong Wang, Professor, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. wangxrnj@gmail.com
Article-Type of This Article
Original Article
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World J Gastrointest Oncol. Jan 15, 2012; 4(1): 9-15 Published online Jan 15, 2012. doi: 10.4251/wjgo.v4.i1.9
Association between IRS-2 G1057D polymorphism and risk of gastric cancer
Xiao-Mei Zhao, Jie Chen, Li Yang, Xuan Luo, Lin-Lin Xu, Dong-Xiao Liu, Su-Lan Zhai, Ping Li, Xue-Rong Wang
Xiao-Mei Zhao, Xuan Luo, Lin-Lin Xu, Su-Lan Zhai, Ping Li, Xue-Rong Wang, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Jie Chen, Department of Pharmacy, the Affiliated Pingxiang Hospital, Southern Medical University, Pingxiang 337000, Jiangxi Province, China
Li Yang, Dong-Xiao Liu, Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Zhao XM participated in the study design, conducted polymerase chain reaction-restriction fragment length polymorphism, analyzed the data and wrote the manuscript; Chen J participated in the study design and data analysis; Luo X, Xu LL, Zhai SL, Li P and Liu DX participated in purification of genomic DNA from all blood samples; Yang L collected blood samples from the first Affiliated Hospital of Nanjing Medical University; Wang XR designed and coordinated the study and revised the manuscript.
Supported by The National Natural Science Foundation of China, No. 30873099; Nanjing Medical University start-up research fund for Wang XR
Correspondence to: Xue-Rong Wang, Professor, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. wangxrnj@gmail.com
Telephone: +86-25-86862884 Fax: +86-25-86862884
Received: August 7, 2011 Revised: December 13, 2011 Accepted: December 20, 2011 Published online: January 15, 2012
Abstract
AIM: To investigate the relationship between insulin receptor substrate-2 (IRS-2) G1057D polymorphism and the risk of gastric cancer (GC) in a Chinese population.
METHODS: A case-control study with 197 GC patients and 156 age- and sex- matched control subjects was conducted. The genotypes of polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTS: The genotype frequencies of IRS-2 G1057D polymorphism in cases were obviously different from those in the control group (P = 0.031). Compared with GG genotype carriers, the risk for GC was significantly higher (adjusted odds ratio = 2.32, 95% CI: 1.03-5.23, P = 0.042) in the individuals with the IRS-2 DD genotype. Furthermore, stratified analysis was performed based on age, sex, smoking status and residence, but no significant difference between the two groups was found. In addition, no significant association between genotypes and clinicopathological features was observed either.
CONCLUSION: This study demonstrates that IRS-2 G1057D is involved in susceptibility to GC, although further large-sample studies are still needed.
