Yang MD, Tsai RY, Liu CS, Chang CH, Wang HC, Tsou YA, Wang CH, Lin CC, Shyue SK, Bau DT. Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan. World J Gastrointest Oncol 2010; 2(8): 326-331 [PMID: 21160894 DOI: 10.4251/wjgo.v2.i8.326]
Corresponding Author of This Article
Da-Tian Bau, MD, Associate Professor, Chairman, Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China. datian@mail.cmuh.org.tw
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Yang MD, Tsai RY, Liu CS, Chang CH, Wang HC, Tsou YA, Wang CH, Lin CC, Shyue SK, Bau DT. Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan. World J Gastrointest Oncol 2010; 2(8): 326-331 [PMID: 21160894 DOI: 10.4251/wjgo.v2.i8.326]
Mei-Due Yang, Chao-Hsiang Chang, Hwei-Chung Wang, Department of Surgery, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China
Cheng-Chieh Lin, Chiu-Shong Liu, Department of Family Medicine, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China
Da-Tian Bau, Chung-Hsing Wang, Yung-An Tsou, Ru-Yin Tsai, Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China
Song-Kun Shyue, Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan, China
Author contributions: Yang MD designed the research; Yang MD, Liu CS and Tsai RY contributed equally to this work; Bau DT and Tsai RY performed all measurements and evaluated the raw data; Tsou YA and Wang CH performed the statistical analyses; Shyue SK selected and evaluated all cases; Chang CH and Lin CC wrote the manuscript with support from Yang MD; all authors approved the final manuscript.
Supported by Research Grants from the China Medical University and Hospital (DMR-99-041 and CMU-99-NTU-10), the Terry Fox Cancer Research Foundation and the National Science Council (NSC 98-2320-B-039-010-MY3).
Correspondence to: Da-Tian Bau, MD, Associate Professor, Chairman, Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China. datian@mail.cmuh.org.tw
Telephone: +886-422052121 Fax: +886-422053366
Received: June 10, 2010 Revised: August 4, 2010 Accepted: August 9, 2010 Published online: August 15, 2010
Abstract
AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.
METHODS: Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.
RESULTS: There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10-12 and 3.0 × 10-4) and allelic frequencies (P = 2.3 × 10-13 and 4.0 × 10-5) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility.
CONCLUSION: This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.
