Zhou Y, Duan H, Chen ZY, He DX. Endoscopic treatment of calcifying fibrous tumor of the esophagus combined with esophageal cancer: A case report. World J Gastrointest Oncol 2026; 18(11): 124574 [DOI: 10.4251/wjgo.124574]
Corresponding Author of This Article
Dao-Xing He, MD, Chief Physician, Department of Gastroenterology, Xuancheng People’s Hospital, Affiliated Xuancheng Hospital of Wannan Medical University, No. 15 North Ring Road, Xuancheng 242000, Anhui Province, China. he_daoxing@qq.com
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Gastroenterology & Hepatology
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case-report
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Zhou Y, Duan H, Chen ZY, He DX. Endoscopic treatment of calcifying fibrous tumor of the esophagus combined with esophageal cancer: A case report. World J Gastrointest Oncol 2026; 18(11): 124574 [DOI: 10.4251/wjgo.124574]
World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124574 Published online Nov 15, 2026. doi: 10.4251/wjgo.124574
Endoscopic treatment of calcifying fibrous tumor of the esophagus combined with esophageal cancer: A case report
Yu Zhou, Hui Duan, Zhao-Yi Chen, Dao-Xing He
Yu Zhou, Hui Duan, Zhao-Yi Chen, Dao-Xing He, Department of Gastroenterology, Xuancheng People’s Hospital, Affiliated Xuancheng Hospital of Wannan Medical University, Xuancheng 242000, Anhui Province, China
Author contributions: Zhou Y drafted the manuscript, conducted the literature review, and assisted in patient management; Duan H performed the endoscopic procedures; Chen ZY was responsible for clinical management of the patient; He DX performed the endoscopic procedures, critically revised the manuscript, and had primary responsibility for the final content; all authors have read and approved the final manuscript.
AI contribution statement: AI tools were used solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Dao-Xing He, MD, Chief Physician, Department of Gastroenterology, Xuancheng People’s Hospital, Affiliated Xuancheng Hospital of Wannan Medical University, No. 15 North Ring Road, Xuancheng 242000, Anhui Province, China. he_daoxing@qq.com
Received: June 22, 2026 Revised: August 2, 2026 Accepted: September 4, 2026 Published online: November 15, 2026 Processing time: 130 Days and 19.6 Hours
Abstract
BACKGROUND
Calcifying fibrous tumor (CFT) is a rare benign neoplasm that uncommonly involves the esophagus. We present a case of esophageal CFT occurring concomitantly with synchronous esophageal squamous cell carcinoma (ESCC).
CASE SUMMARY
A 69-year-old patient with dysphagia was found to have an esophageal mass on computed tomography. Gastroscopy identified a submucosal tumor (21-24 cm from the incisors) and an adjacent mucosal lesion (24-26 cm). Biopsy of the mucosal lesion revealed high-grade intraepithelial neoplasia. The submucosal tumor was excised via submucosal tunneling endoscopic resection (STER), and the mucosal lesion was resected by endoscopic submucosal dissection (ESD) in the same procedure. Pathological examination confirmed the diagnosis of CFT and moderately differentiated ESCC (1.5 cm × 1.6 cm), with submucosal invasion to a depth of 1000 μm, negative surgical margins, and no evidence of lymphovascular or perineural invasion. Additional therapy was advised but declined by the patient. Telephone follow-up at 3, 6, and 12 months postoperatively reported no symptomatic complaints; however, no objective endoscopic or imaging surveillance was undertaken.
CONCLUSION
The combination of STER and ESD is technically achievable for synchronous esophageal lesions; nevertheless, its endorsement as a standard therapeutic option is precluded by the limitations inherent to a single case with incomplete post-procedural surveillance.
Core Tip: We present a case of synchronous esophageal calcifying fibrous tumor and esophageal squamous cell carcinoma in a 69-year-old man. The lesions were effectively treated in a single session using combined submucosal tunneling endoscopic resection and endoscopic submucosal dissection. This case underscores the technical viability of this combined strategy, highlights the diagnostic ambiguity of type B2 intrapapillary capillary loop changes in preoperative depth assessment, and emphasizes the necessity of rigorous postoperative surveillance to ensure oncological safety.
