Nomogram-based strategy to predict relapse-free survival in patients with gastrointestinal stromal tumor using inflammatory indicators

Abstract

Zhao et al’s investigation on the assessment of inflammatory markers prognostic value for relapse-free survival in patients with gastrointestinal stromal tumor (GIST) using a nomogram-based approach is a scientific approach. This study explored the potential of an inflammatory marker-based nomograph model, highlighting the relapse-free survival-associated risk factors prognostic potential in patients with GIST. The author assessed 124 samples from patients with GIST to find an association between inflammatory markers and tumor size in a retrospective study using multivariate regression analysis. Further, a nomogram model was developed to identify the independent risk factors for the prognosis. GIST clinical treatment can use preoperative monocyte/lymphocyte ratio and platelet/lymphocyte ratio for relapse-free survival prognosis as independent factors.

Keywords: Recurrence-free survival; Gastrointestinal stromal tumor; Nomogram model; Inflammatory markers; Independent risk factor; Cancer

Core Tip: This retrospective study evaluated inflammatory indicators' predictive significance for relapse-free survival in patients with gastrointestinal stromal tumor (GIST) utilizing a nomogram-based technique. The author tried to associate test preoperative inflammatory indicators with recurrence-free survival. The study created a GIST prognostic nomogram using inflammatory markers, but the limitation(s) and its possible effect on the outcome of GIST prognosis were not discussed. Inclusion and exclusion criteria should be broad enough to minimize the false-positive effects of immune marker levels in test samples. Normalization of inflammatory markers in response to different chemotherapeutic drug(s) is important for obtaining a stable prognostic outcome in GIST.