Qian ST, Zhao HY, Xie FF, Liu QS, Cai DL. Streptococcus anginosus in the development and treatment of precancerous lesions of gastric cancer. World J Gastrointest Oncol 2024; 16(9): 3771-3780 [PMID: 39350992 DOI: 10.4251/wjgo.v16.i9.3771]
Corresponding Author of This Article
Dan-Li Cai, MM, Associate Chief Physician, Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 1 Gaojiao Road, Yuhang District, Hangzhou 311122, Zhejiang Province, China. 13858159603@139.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2024; 16(9): 3771-3780 Published online Sep 15, 2024. doi: 10.4251/wjgo.v16.i9.3771
Streptococcus anginosus in the development and treatment of precancerous lesions of gastric cancer
Su-Ting Qian, Hao-Yu Zhao, Fei-Fei Xie, Qing-Sheng Liu, Dan-Li Cai
Su-Ting Qian, Hao-Yu Zhao, Fei-Fei Xie, Department of Digestive, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, Zhejiang Province, China
Qing-Sheng Liu, Science and Education Section, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, Zhejiang Province, China
Dan-Li Cai, Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 311122, Zhejiang Province, China
Co-corresponding authors: Qing-Sheng Liu and Dan-Li Cai.
Author contributions: Qian ST, Zhao HY, Xie FF, Liu QS and Cai DL contributed to this paper; Cai DL and Liu QS conceptualized and designed the research; Qian ST contributed to the design and writing of the manuscript; Zhao HY and Xie FF contributed to the editing the manuscript and review of literature; All the authors have read and approved the final manuscript. Both Cai DL and Liu QS have played important and indispensable roles in the designed the overall concept, outline of the manuscript and manuscript preparation as the co-corresponding authors. Liu QS searched the literature and submitted an earlier version of the manuscript focusing on the relationship between Streptococcus anginosus and Precancerous lesions of gastric cancer. Cai DL Responsible for the analysis and interpretation of relevant concepts, comprehensive literature search, preparation and submission of the current version of the manuscript. This collaboration between Liu QS and Cai DL is crucial for the publication of this manuscript and other manuscripts still in preparation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Li Cai, MM, Associate Chief Physician, Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 1 Gaojiao Road, Yuhang District, Hangzhou 311122, Zhejiang Province, China. 13858159603@139.com
Received: April 12, 2024 Revised: May 22, 2024 Accepted: June 6, 2024 Published online: September 15, 2024 Processing time: 149 Days and 23 Hours
Abstract
The microbiota is strongly association with cancer. Studies have shown significant differences in the gastric microbiota between patients with gastric cancer (GC) patients and noncancer patients, suggesting that the microbiota may play a role in the development of GC. Although Helicobacter pylori (H. pylori) infection is widely recognized as a primary risk factor for GC, recent studies based on microbiota sequencing technology have revealed that non-H. pylori microbes also have a significant impact on GC. A recent study discovered that Streptococcus anginosus(S. anginosus) is more prevalent in the gastric mucosa of patients with GC than in that of those without GC. S. anginosus infection can spontaneously induce chronic gastritis, mural cell atrophy, mucoid chemotaxis, and heterotrophic hyperplasia, which promote the development of precancerous lesions of GC (PLGC). S. anginosus also disrupts the gastric barrier function, promotes the proliferation of GC cells, and inhibits apoptosis. However, S. anginosus is underrepresented in the literature. Recent reports suggest that it may cause precancerous lesions, indicating its emerging pathogenicity. Modern novel molecular diagnostic techniques, such as polymerase chain reaction, genetic testing, and Ultrasensitive Chromosomal Aneuploidy Detection, can be used to gastric precancerous lesions via microbial markers. Therefore, we present a concise summary of the relationship between S. anginosus and PLGC. Our aim was to further investigate new methods of preventing and treating PLGC by exploring the pathogenicity of S. anginosus on PLGC.
Core Tip: Advanced gastric cancer has a very poor prognosis at this stage. Early diagnosis and treatment of precancerous lesions of gastric cancer (PLGC) still need further research. Studies of the microbiota associated with PLGC have found that Streptococcus anginosus (S. anginosus) plays an important role in their development. We explore the mechanism of S. anginosus in PLGC and consider its inclusion in the diagnosis and treatment of PLGC.
