Risk factors for the prognosis of colon cancer

Abstract

A study on clinical outcomes and prognostic factors in T4N0M0 colon cancer patients after R0 resection revealed that ileostomy, T stage, right hemicolectomy, irregular follow-up, and CA199 level were independent risk factors affecting overall survival. T4-stage cancer invades the entire thickness of the intestinal tract, increasing the difficulty of treatment and the risk of recurrence, and requires a combination of chemotherapy, immunotherapy, and targeted therapy to control the spread of cancer cells. The prognosis of right hemicolectomy is significantly worse than that of left hemicolectomy, and right hemicolectomy is an independent risk factor for a poor prognosis. Advanced age, histopathological type, and lymph node metastasis are also risk factors for colon cancer.

Keywords: Risk factor; Prognosis; Colon cancer; Tumour stage; Right hemicolectomy

Core Tip: The incidence and mortality rates of colon cancer are increasing; while most cases involve advanced-stage disease, T4-stage disease is rare and poorly studied. Survival time is an important indicator of treatment effectiveness, and this study identified multiple independent risk factors. T4-stage cancer invades the entire thickness of the intestinal tract, increasing the difficulty of treatment and the risk of recurrence, and requires a combination of multiple treatment methods. The prognosis of right hemicolectomy is worse than that of left hemicolectomy, and right hemicolectomy is an independent risk factor for a poor prognosis. Advanced age, histopathological type, and lymph node metastasis are also risk factors.