Wu CY, Ye K. Risk factors for the prognosis of colon cancer. World J Gastrointest Oncol 2024; 16(8): 3738-3740 [PMID: 39171168 DOI: 10.4251/wjgo.v16.i8.3738]
Corresponding Author of This Article
Kai Ye, MD, Chief Doctor, Dean, Professor, Research Dean, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou 362000, Fujian Province, China. medwcy@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3738-3740 Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3738
Risk factors for the prognosis of colon cancer
Chu-Ying Wu, Kai Ye
Chu-Ying Wu, Kai Ye, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Author contributions: Wu CY contributed to original draft preparation, writing and editing; Kai Y contributed to conceptualization, supervision, and funding acquisition; all authors have read and approved the final manuscript.
Supported byKey Clinical Specialty Discipline Construction Program of Fujian, Fujian Health Medicine and Politics, No. [2022] 884.
Conflict-of-interest statement: All authors report no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai Ye, MD, Chief Doctor, Dean, Professor, Research Dean, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou 362000, Fujian Province, China. medwcy@163.com
Received: May 19, 2024 Revised: June 25, 2024 Accepted: July 8, 2024 Published online: August 15, 2024 Processing time: 80 Days and 22.6 Hours
Abstract
A study on clinical outcomes and prognostic factors in T4N0M0 colon cancer patients after R0 resection revealed that ileostomy, T stage, right hemicolectomy, irregular follow-up, and CA199 level were independent risk factors affecting overall survival. T4-stage cancer invades the entire thickness of the intestinal tract, increasing the difficulty of treatment and the risk of recurrence, and requires a combination of chemotherapy, immunotherapy, and targeted therapy to control the spread of cancer cells. The prognosis of right hemicolectomy is significantly worse than that of left hemicolectomy, and right hemicolectomy is an independent risk factor for a poor prognosis. Advanced age, histopathological type, and lymph node metastasis are also risk factors for colon cancer.
Core Tip: The incidence and mortality rates of colon cancer are increasing; while most cases involve advanced-stage disease, T4-stage disease is rare and poorly studied. Survival time is an important indicator of treatment effectiveness, and this study identified multiple independent risk factors. T4-stage cancer invades the entire thickness of the intestinal tract, increasing the difficulty of treatment and the risk of recurrence, and requires a combination of multiple treatment methods. The prognosis of right hemicolectomy is worse than that of left hemicolectomy, and right hemicolectomy is an independent risk factor for a poor prognosis. Advanced age, histopathological type, and lymph node metastasis are also risk factors.
