Feng Q, Yu W, Feng JH, Huang Q, Xiao GX. Jejunal sarcomatoid carcinoma: A case report and review of literature. World J Gastrointest Oncol 2024; 16(8): 3723-3731 [PMID: 39171179 DOI: 10.4251/wjgo.v16.i8.3723]
Corresponding Author of This Article
Qiao Huang, MD, Professor, The First College of Clinical Medical Science, China Three Gorges University, No. 183 Yiling Road, Yichang 443000, Hubei Province, China. huqi70@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Qian Feng, Wei Yu, Jing-Hui Feng, Qiao Huang, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China
Qian Feng, Wei Yu, Jing-Hui Feng, Qiao Huang, Department of Oncology, Yichang Central People's Hospital, Yichang 443000, Hubei Province, China
Gui-Xiang Xiao, Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Co-first authors: Qian Feng and Wei Yu.
Author contributions: Feng Q drafted the manuscript; Feng Q and Yu W revised the manuscript; Huang Q critically revised the article and ensured that questions related to the integrity of any part of the work were appropriately investigated and resolved; Feng JH and Xiao GX provided guidance on professional knowledge; Feng Q, Yu W, Feng JH, Xiao GX confirm the authenticity of all the raw data; All authors read and approved the final version of the manuscript.
Informed consent statement: Written informed consent has been obtained from the patient to publish this paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read CARE Checklist (2016), and the manuscript was prepared and revised according to CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiao Huang, MD, Professor, The First College of Clinical Medical Science, China Three Gorges University, No. 183 Yiling Road, Yichang 443000, Hubei Province, China. huqi70@163.com
Received: April 16, 2024 Revised: June 3, 2024 Accepted: June 17, 2024 Published online: August 15, 2024 Processing time: 114 Days and 3.3 Hours
Abstract
BACKGROUND
Sarcomatoid carcinoma (SCA) of the jejunum is a rare and aggressive neoplasm affecting the smooth muscle cells of the jejunum. This study presents a recent case of jejunal SCA, detailing its diagnosis and treatment, thereby providing a reference for clinical practice.
CASE SUMMARY
A 65-year-old male presented to Yichang Central People's Hospital with a chief complaint of hemorrhoids. A computed tomography (CT) scan incidentally revealed multiple abnormal signals in the liver. Subsequent positron emission tomography/CT at Wuhan Union Hospital indicated malignant tumor progression, with a primary duodenal tumor and multiple metastases in the upper left abdomen. Intraoperatively, a large tumor was identified on the omentum. Histopathological and immunohistochemical analyses of the resected specimen confirmed the diagnosis of jejunal SCA. The patient received a combination therapy of sintilimab, nanoparticle albumin-bound paclitaxel, and anlotinib. Follow-up imaging demonstrated significant reduction of hepatic and peritoneal lesions. The patient has remained stable for over one year postoperatively.
CONCLUSION
This case suggests that chemotherapy, immunotherapy, plus targeted therapy may represent an optimal treatment for intestinal SCA, meriting further investigation.
Core Tip: Sarcomatoid carcinoma (SCA) of the jejunum is a rare and aggressive malignancy. Currently, there are no established treatment guidelines for SCA. This study reports a patient who achieved favorable outcomes with a combination of immunotherapy, targeted therapy, and chemotherapy. A review of the literature was also conducted. We propose that this therapeutic approach may represent a novel treatment option for jejunal SCA.
