Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis

doi:10.4251/wjgo.v16.i8.3705

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 8

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3801)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-6) series, Tables (1-5) series.

Item

Count

PDF

240

HTML

1778

Figures (1-6)

395

Tables (1-5)

378

Sum=2791

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

137

Download

731

Sum=868

Aug 15, 2024 (publication date) through Feb 15, 2026

Times Cited of This Article

Times Cited (2)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Scientometrics

World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3705-3715
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3705

Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis

Hui-Min Li, Yin Liu, Meng-Di Hao, Xiao-Qing Liang, Da-Jin Yuan, Wen-Bin Huang, Wen-Jie Li, Lei Ding

Hui-Min Li, Yin Liu, Meng-Di Hao, Xiao-Qing Liang, Da-Jin Yuan, Wen-Bin Huang, Wen-Jie Li, Lei Ding, Department of Gastrointestinal Oncology Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

Author contributions: Li HM contributed to the conception and design of the study, and drafted and revised the manuscript; Liu Y and Hao MD are responsible for literature searching and data collection; Liang XQ and Yuan DJ are responsible for statistical analysis and charting; Huang WB and Li WJ checked the manuscript for grammar and spelling; Ding L coordinated the design and facilities for this study, provided multiple support in terms of personnel, materials and methods for the conduct of this study. All authors all approved the final manuscript.

Supported by the National Natural Science Foundation of China, No. 82170525; and Beijing Shijitan Hospital Professionals Training Program, No. 2023 LJRCDL.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Corresponding author: Lei Ding, MD, Chief Doctor, Department of Gastrointestinal Oncology Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyilu, Yangfangdian, Haidian District, Beijing 100038, China. dinglei1005@126.com

Received: May 7, 2024
Revised: June 11, 2024
Accepted: July 1, 2024
Published online: August 15, 2024
Processing time: 93 Days and 2.1 Hours

Abstract

BACKGROUND

Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Over the past two decades, numerous researchers have provided important evidence regarding the role of tight junction (TJ) proteins in the occurrence and progression of CRC. The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed. Despite the large number of publications in this field, a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.

AIM

To analyze research on TJs and CRC, summarize the field’s history and current status, and predict future research directions.

METHODS

We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023. We used bibliometrics to analyze the data of these papers, such as the authors, countries, institutions, and references. Co-authorship, co-citation, and co-occurrence analyses were the main methods of analysis. CiteSpace and VOSviewer were used to visualize the results.

RESULTS

A total of 205 studies were ultimately identified. The number of publications on this topic has steadily increased since 2007. China and the United States have made the largest contributions to this field. Anticancer Research was the most prolific journal, publishing 8 articles, while the journal Oncogene had the highest average citation rate (68.33). Professor Dhawan P was the most prolific and cited author in this field. Co-occurrence analysis of keywords revealed that “tight junction protein expression”, “colorectal cancer”, “intestinal microbiota”, and “inflammatory bowel disease” had the highest frequency of occurrence, revealing the research hotspots and trends in this field.

CONCLUSION

This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC, providing valuable research perspectives and future directions for studying the connection between the two. It is recommended to focus on emerging research hotspots, such as the correlations among intestinal microbiota, inflammatory bowel disease, TJ protein expression, and CRC.

Keywords: Colorectal cancer; Tight junctions; Bibliometric analysis; Research trends; Hot spots

Core Tip: This bibliometric analysis evaluated the scope and trends of tight junction (TJ) proteins in colorectal cancer (CRC), providing valuable research perspectives and future directions for studying the connection between the two. It is recommended to focus on emerging hotspots such as the correlations among intestinal microbiota, inflammatory bowel disease, TJ protein expression, and CRC.