Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3687
Revised: May 26, 2024
Accepted: June 17, 2024
Published online: August 15, 2024
Processing time: 209 Days and 13.8 Hours
Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field.
To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression.
Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks.
From 2001 to 2022, Supportive Care in Cancer, the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity.
Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.
Core Tip: Colorectal cancer (CRC) is the third leading cause of cancer-related death. The impact of psychological disorders on the treatment of CRC is significant, Patients with severe psychological disorders experience reduced quality of life, poor treatment compliance, prolonged recovery time, abnormal disease behavior, damage to social relationships, and poor survival. There is no systematic summary and comparison of the status and trend of research on the impact of depression on CRC. Bibliometric analysis is known as a method of rigorous, quantitative analysis of a large volume of data contained in the scientific literature. It is necessary to investigate the relationship between CRC and depression.