Zheng LP, Shen WY, Hu CD, Wang CH, Chen XJ, Wang J, Shen YY. Undifferentiated high-grade pleomorphic sarcoma of the common bile duct: A case report and review of literature. World J Gastrointest Oncol 2024; 16(5): 2253-2260 [PMID: 38764812 DOI: 10.4251/wjgo.v16.i5.2253]
Corresponding Author of This Article
Yi-Yu Shen, MD, Chief Physician, Department of General Surgery, The Second Affiliated Hospital of Jiaxing University, No. 1518 Huancheng North Road, Jiaxing 314000, Zhejiang Province, China. drzlping@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
May 15, 2024 (publication date) through Mar 14, 2026
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Zheng LP, Shen WY, Hu CD, Wang CH, Chen XJ, Wang J, Shen YY. Undifferentiated high-grade pleomorphic sarcoma of the common bile duct: A case report and review of literature. World J Gastrointest Oncol 2024; 16(5): 2253-2260 [PMID: 38764812 DOI: 10.4251/wjgo.v16.i5.2253]
Li-Ping Zheng, Chun-Dong Hu, Xu-Jian Chen, Jing Wang, Yi-Yu Shen, Department of General Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Wen-Yan Shen, Chun-Hua Wang, Department of Pathology, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Co-first authors: Li-Ping Zheng and Wen-Yan Shen.
Co-corresponding authors: Jing Wang and Yi-Yu Shen.
Author contributions: Zheng LP, Wang J and Shen YY concepted and designed the case report; Zheng LP, Shen WY and Hu CD collected the clinicopathologic data of the patient; Shen WY and Wang CH provided and explained the pathological pictures; Zheng LP, Shen WY, Chen XJ, Wang J and Shen YY analyzed the data; Zheng LP, Wang J and Shen YY wrote the manuscript; All the authors have read and approved the final manuscript. Zheng LP conceived, designed the case, collected and analyzed the data, and wrote the first draft of the manuscript. Shen WY was responsible for the collection and processing of tissue specimens, as well as pathological diagnosis. Both authors have made vital and indispensable contributions to the completion of the case and are therefore eligible to be co-first authors of the paper. As co-corresponding authors, Wang J and Shen YY played an important and indispensable roles in case design, data analysis and manuscript preparation.
Supported bythe People’s Livelihood Science and Technology Innovation Project of the Bureau of Science and Technology of Jiaxing City, No. 2021AD30091.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yi-Yu Shen, MD, Chief Physician, Department of General Surgery, The Second Affiliated Hospital of Jiaxing University, No. 1518 Huancheng North Road, Jiaxing 314000, Zhejiang Province, China. drzlping@126.com
Received: January 24, 2024 Peer-review started: January 24, 2024 First decision: January 31, 2024 Revised: February 7, 2024 Accepted: March 25, 2024 Article in press: March 25, 2024 Published online: May 15, 2024 Processing time: 106 Days and 1.5 Hours
Abstract
BACKGROUND
Undifferentiated pleomorphic sarcoma (UPS) is a rare malignant mesenchymal tumor with a poor prognosis. It mainly occurs in the extremities, trunk, head and neck, and retroperitoneum regions. Owing to the lack of specific clinical manifestations and imaging features, UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive diagnosis. Here we report an extremely rare case of high-grade UPS in the common bile duct (CBD). There are limited available data on such cases.
CASE SUMMARY
A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 wk. Her laboratory data suggested significantly elevated hepatorenal function levels. The imaging data revealed calculous cholecystitis, intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi, and a space-occupying lesion at the distal CBD. After endoscopic biliary stenting and symptomatic support therapy, CBD exploration and biopsy were performed. The frozen section indicated malignant spindle cell tumor of the CBD mass, and further radical pancreaticoduodenectomy was performed. Finally, the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical results.
CONCLUSION
This extremely rare case highlighted the need for increasing physicians' vigilance, reducing the odds of misdiagnosis, and providing appropriate treatment strategies.
Core Tip: Undifferentiated pleomorphic sarcoma (UPS) cases are rare. Herein, we report the case of an elderly woman with high-grade UPS, which was detected because of obstructive jaundice and diagnosed by histopathology. As far as we know, this is the first reported case of UPS in the common bile duct (CBD). Recognizing that UPS can occur in the CBD will help increase physicians' vigilance, reduce the odds of misdiagnosis, and provide appropriate treatment strategies.
