Guan XL, Guan XY, Zhang ZY. Roles and application of exosomes in the development, diagnosis and treatment of gastric cancer. World J Gastrointest Oncol 2024; 16(3): 630-642 [PMID: 38577463 DOI: 10.4251/wjgo.v16.i3.630]
Corresponding Author of This Article
Zheng-Yi Zhang, MD, Professor, Department of General Medicine, The Second Hospital of Lanzhou University, No. 82 Cuiying Gate, Chengguan District, Lanzhou 730030, Gansu Province, China. zhangzhengyi11@lzu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 630-642 Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.630
Roles and application of exosomes in the development, diagnosis and treatment of gastric cancer
Xiao-Li Guan, Xiao-Ying Guan, Zheng-Yi Zhang
Xiao-Li Guan, Zheng-Yi Zhang, Department of General Medicine, The Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
Xiao-Ying Guan, Department of Pathology, The Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
Co-first authors: Xiao-Li Guan and Xiao-Ying Guan.
Author contributions: All authors contributed to the original ideas and writing of this paper; Guan XL and Guan XY contributed equally to this work; Guan XL and Guan XY drafted the article and draw figures; Zhang ZY made critical revisions of this paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng-Yi Zhang, MD, Professor, Department of General Medicine, The Second Hospital of Lanzhou University, No. 82 Cuiying Gate, Chengguan District, Lanzhou 730030, Gansu Province, China. zhangzhengyi11@lzu.edu.cn
Received: October 14, 2023 Peer-review started: October 14, 2023 First decision: December 15, 2023 Revised: December 18, 2023 Accepted: January 15, 2024 Article in press: January 15, 2024 Published online: March 15, 2024 Processing time: 149 Days and 18.4 Hours
Abstract
As important messengers of intercellular communication, exosomes can regulate local and distant cellular communication by transporting specific exosomal contents and can also promote or suppress the development and progression of gastric cancer (GC) by regulating the growth and proliferation of tumor cells, the tumor-related immune response and tumor angiogenesis. Exosomes transport bioactive molecules including DNA, proteins, and RNA (coding and noncoding) from donor cells to recipient cells, causing reprogramming of the target cells. In this review, we will describe how exosomes regulate the cellular immune response, tumor angiogenesis, proliferation and metastasis of GC cells, and the role and mechanism of exosome-based therapy in human cancer. We will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treatment of GC and their relationship with drug resistance.
Core Tip: Exosome-mediated transport plays an important role in the invasion and metastasis of gastric cancer (GC). In this review, we focus on the immunoregulatory role of exosomes and the relationship between exosomes and GC, with special attention to their role in the growth, invasion, metastasis, and therapeutic resistance of GC, as well as their potential clinical application value as biomarkers and therapeutic targets, and the mechanism and clinical application prospects of exosomal immunotherapy for human tumors.
