Xu QD, Liu H, Zhang HW, Gao XM, Li YG, Wu ZY. Effect of endoscopic submucosal dissection on gastrointestinal function and nutritional status in patients with early gastric cancer. World J Gastrointest Oncol 2024; 16(11): 4402-4408 [PMID: 39554754 DOI: 10.4251/wjgo.v16.i11.4402]
Corresponding Author of This Article
Zuo-Yan Wu, PhD, Chief Physician, Department of Gastroenterology, Beijing No. 6 Hospital, No. 36 North Ertiao Road, Intersection, Dongcheng District, Beijing 100007, China. wzy1989910@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Qi-De Xu, Xiao-Mao Gao, Ying-Guang Li, Zuo-Yan Wu, Department of Gastroenterology, Beijing No. 6 Hospital, Beijing 100007, China
Hua Liu, Department of Gastroenterology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin 300162, China
Hui-Wen Zhang, Department of Nursing, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China
Co-first authors: Qi-De Xu and Hua Liu.
Author contributions: Xu QD and Wu ZY designed the study; Zhang HW, Gao XM, Li YG, and Wu ZY contributed to the analysis of the manuscript; Xu QD and Liu H involved in the data and writing of this article; all authors have read and approved the final manuscript. Xu QD and Liu H contributed equally to this work as co-first authors. They jointly participated in the designing and planning of the research, proposed innovative research ideas and methods, laid the foundation for the smooth progress of the research. They played a crucial role in data collection and organization, rigorously screened and organized patient data to ensure accuracy and completeness. They jointly undertook the important tasks of data analysis and interpretation. Meaningful research conclusions were drawn through in-depth exploration and comprehensive judgment, and core viewpoints and important arguments were contributed during the paper writing process.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Beijing No. 6 Hospital.
Informed consent statement: All study participants and their legal guardians provided written informed consent before enrolment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zuo-Yan Wu, PhD, Chief Physician, Department of Gastroenterology, Beijing No. 6 Hospital, No. 36 North Ertiao Road, Intersection, Dongcheng District, Beijing 100007, China. wzy1989910@126.com
Received: August 6, 2024 Revised: August 30, 2024 Accepted: September 5, 2024 Published online: November 15, 2024 Processing time: 80 Days and 1.4 Hours
Abstract
BACKGROUND
Gastric cancer (GC) endangers the survival and prognosis of patients worldwide. Improving the prognosis of patients with early GC (EGC) is crucial to prolong their survival time.
AIM
To analyze the effects of endoscopic submucosal dissection (ESD) on gastrointestinal function and nutritional status in patients with EGC.
METHODS
Eighty patients with EGC between January 2021 and January 2024 were divided according to different surgical protocol into following two groups: 42 patients who underwent ESD in the ESD group and 38 patients treated with endoscopic mucosal resection (EMR) in the EMR group. Two groups were compared in the operative indices, lesion resection rate, postoperative recovery of gastrointestinal function, nutritional status, and incidence of surgical complications.
RESULTS
The overall resection rate of the lesion in the ESD group was higher. The operative bleeding volume and operation time were higher and gastrointestinal ventilation time was shorter in the ESD group than those in the EMR group (P< 0.05). The nutritional statuses of the two groups decreased after operation; however, the levels of albumin, prealbumin, hemoglobin, and transferrin were higher in the ESD group than in the EMR group (P < 0.05). The post-operative pepsinogen (PG) I level in the ESD group was higher than that in the EMR group, and the PG II level was lower than that in the EMR group (P < 0.05). The incidence of postoperative complications was compared between the two groups (P > 0.05).
CONCLUSION
ESD can promote the immediate recovery of patient’s postoperative gastrointestinal function, improve their nutritional level, and signifies its application in patients with EGC.
Core Tip: Endoscopic submucosal dissection (ESD) application in patients with early gastric cancer (EGC) can significantly promote the recovery of gastrointestinal function, improve nutritional status, and reduce complications. This study confirmed the effectiveness of ESD in promoting the recovery of gastrointestinal function by observing the changes in gastrointestinal function and nutritional status in patients with EGC.
