Overgrowth of Lactobacillus in gastric cancer

doi:10.4251/wjgo.v13.i9.1099

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Sep 15, 2021; 13(9): 1099-1108
Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.1099

Overgrowth of Lactobacillus in gastric cancer

Quan-Jiang Dong, Zong-Hao Guo, Lin Xu, Li-Li Wang, Lin-Lin Lu, Ju-Xin Liu, Zhi-Peng Li

Zhi-Peng Li, Lin-Lin Lu, Li-Li Wang, Lin Xu, Quan-Jiang Dong, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong Province, China

Ju-Xin Liu, Clinical Laboratories, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China

Zong-Hao Guo, Department of Clinical Medicine, Jining Medical University, Jining 272000, Shandong Province, China

Author contributions: Li ZP and Guo ZH collected the literature; Li ZP and Lu LL analyzed the data and wrote the manuscript; Liu JX, Wang LL, and Xu L reviewed the literature and wrote the discussion part of the manuscript; Dong QJ designed the research and supervised the manuscript; all authors reviewed the manuscript and approved the final version of the manuscript.

Supported by The National Natural Science Foundation of China, No. 31870777.

Conflict-of-interest statement: The authors declare no conflict of interests for this article.

Corresponding author: Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Central Laboratories, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. allyking114@126.com

Received: February 22, 2021
Peer-review started: February 22, 2021
First decision: April 19, 2021
Revised: April 30, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: September 15, 2021
Processing time: 200 Days and 4.5 Hours

Abstract

Dysbiosis of the gastric microbiome is involved in the development of gastric cancer (GC). A number of studies have demonstrated an increase in the relative abundance of Lactobacillus in GC. In this review, we present data that support the overgrowth of Lactobacillus in GC from studies on molecular and bacterial culture of the gastric microbiome, discuss the heterogenic effects of Lactobacillus on the health of human stomach, and explore the potential roles of the overgrowth of Lactobacillus in gastric carcinogenesis. Further studies are required to examine the association between Lactobacillus and GC at strain and species levels, which would facilitate to elucidate its role in the carcinogenic process.

Keywords: Lactobacillus; Gastric cancer; Gastritis; Microbiome; Next generation sequencing

Core Tip: Many strains of Lactobacillus have been used as probiotics in the clinical setting. However, recent molecular analyses of the gastric microbiome demonstrate a close association between an increased abundance of Lactobacillus and gastric cancer. In this paper, we review the current understanding of heterogenic effects of Lactobacillus on the health of the human stomach and discuss potential roles of the overgrowth of Lactobacillus in the gastric carcinogenesis.