Brief Article
Copyright ©2009 Baishideng. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2009; 1(1): 82-88
Published online Oct 15, 2009. doi: 10.4251/wjgo.v1.i1.82
Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals
Ramesh L Londonkar, Pramod V Poddar
Ramesh L Londonkar, Department of Studies and Research in Biotechnology, Gulbarga University Gulbarga 585106, Karnataka, India
Pramod V Poddar, Department of Studies and Research in Biotechnology, Gulbarga University Gulbarga 585106, Karnataka, India
Author contributions: Londonkar RL and Poddar PV contributed equally to this work; Londonkar RL designed research; Poddar PV performed research, contributed new reagents/analytical tools; Londonkar RL and Poddar PV analyzed data and wrote the paper.
Correspondence to: Ramesh L Londonkar, Associate Professor, Department of Studies and Research in Biotechnology, Gulbarga University Gulbarga 585106, Karnataka, India. londonkarramesh53@reddiffmail.com
Telephone: +84-72-263290 Fax: +84-72-263206
Received: February 3, 2009
Revised: March 20, 2009
Accepted: March 27, 2009
Published online: October 15, 2009
Abstract

AIM: To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid, ethanol and pylorus ligated ulcer models in rats and mice.

METHODS: Various crude extracts of petroleum ether, chloroform, or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated animals. In the pyloric ligation model oral administration of different extracts such as petroleum ether, chloroform and aqueous at 375 mg/kg po, standard drug ranitidine 60 mg/kg po and control group 1% Tween 80, 5 mL/kg po to separate groups of Wister rats of either sex (n = 6) was performed. Total acidity, ulcer number, scoring, incidence, area, and ulcer index were assessed.

RESULTS: There was a decrease in gastric secretion and ulcer index among the treated groups i.e. petroleum ether (53.4%), chloroform (59.2%), aqueous (67.0%) and in standard drug (68.7%) when compared to the negative control. In the 0.6 mol/L HCl induced ulcer model in rats (n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether (50.5%), chloroform (57.4%), aqueous (67.5%) and standard. drug (71.2%) when compared to the negative control. In the case of the 90% ethanol-induced ulceration model (n = 6) in mice, there was a decrease in ulcer score in test groups of petroleum ether (53.11%), chloroform (62.9%), aqueous (65.4%) and standard drug ranitidine (69.7%) when compared to the negative control. It was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation, 0.6 mol/L HCl and 90% ethanol produced significant action against acid secretion (49.3 ± 0.49 vs 12.0 ± 0.57, P < 0.001). Pre-treatment with various extracts of Mentha arvensis Linn showed highly -significant activity against gastric ulcers (37.1 ± 0.87 vs 12.0 ± 0.57, P < 0.001).

CONCLUSION: Various extracts of Mentha arvensis Linn. 375 mg/kg body weight clearly shows a protective effect against acid secretion and gastric ulcers in ibuprofen plus pyloric ligation, 0.6 mol/L HCl induced and 90% ethanol-induced ulcer models.

Keywords: Mentha arvensis; Anti ulcer; Gastroprotection; Medicinal plant