Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 gene: A case report and review of literature

Table 1 Clinical features of chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 in the 132 published cases, n (%)

Ref.	Country	Number	Age	Female	Clinical presentation					Hb (g/L)	Alb (mg/L)	Endoscopic features							Consanguinity1	PHO
					Anemia	Hypoproteinemia	Abdominal pain	Diarrhea	Gastro intestinal Bleeding			Esophagus	Stomach	Duodenum	Jejunum	Ileum	Colon	Surgery
Hamon et al[8], 2023; Ricard et al[9], 2024; Sun et al[11], 2018; Ariake et al[13], 2022; Chen et al[14], 2025; Dönger et al[15], 2022; Eda et al[16], 2018; Fang et al[17], 2020; Hu et al[18], 2019; Huang et al[19], 2021; Jimbo et al[20], 2020; Kumar et al[21], 2025; Lin et al[22], 2023; Long et al[23], 2022; Prasad et al[24], 2025; Saura et al[25], 2024; Sonoda et al[26], 2020; Sun et al[27], 20212; Tsuzuki et al[28], 2020; Uchida et al[29], 2017; Wang et al[30], 2019	/	31	24.5, (IQR: 4-75)	48.4	93.5	70.9	61.3	25.8	41.9	77.6 (IQR: 25-126)	27.7 (IQR: 14-40)	-	9.7	16.1	35.5	77.4	9.7	45.2	19.4	29.0
Shang et al[1], 2024	China	12	32 (IQR: 29-40)	41.7	66.7	75	100.0	41.7	33.3	67 (IQR: 49-81)	28 (IQR: 22-33)	16.7	50.0	33.3	16.7	91.7	33.3	75.0	33.3	58.3
Lim et al[2], 2024	Korea	11	16 (IQR: 11~20)	36.4	72.7	/	81.8	9.1	18.2	95 (IQR: 72-111)	31 (IQR: 30-37)	-	45.5	63.6	36.4	63.6	-	45.5	/	27.3
Hong et al[3], 2022	Korea	14	44.5 (IQR: 30-50)	85.7	92.9	100.0	100.0	50.0	21.4	96 (IQR: 79-100)	27 (IQR: 21-30)	-	14.3	35.7	42.9	92.9	14.3	50.0	/	35.7
Umeno et al[4], 2018	Japan	46	40 (IQR: 7-69)	71.7	97.8	/	39.1	4.3	4.3	96 (IQR: 23-137)	Serum protein 52 (IQR: 27-82)	-	26.0	48.0	31.0	98.0	-	63.0	28.0	11.0
Umeno et al[5], 2015	Japan	18	41.2 (IQR: 7-66)	77.8	100.0	77.8	33.3	/	/	87.5 (IQR: 48-112)	Serum protein 55.5 (IQR: 38-82)	-	27.8	44.4	-	100	-	77.8	44.4	12.5
Total		132	30 (IQR: 4-75)	60.3	87.3	81.0	69.3	26.2	25.8	86.5 (IQR: 23-137)	28.4 (IQR: 14-40)	16.7	29.0	40.4	32.5	88.2	19.3	59.4	31.3	29.0

¹Consanguinity: The parents of the patient are united by ties of consanguinity.

-: Negative: +: Positive; /: Not provide; Hb: Hemoglobin; Alb: Albumin; PHO: Primary hypertrophic osteoarthropathy; IQR: Interquartile range.