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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Dec 16, 2025; 17(12): 112344
Published online Dec 16, 2025. doi: 10.4253/wjge.v17.i12.112344
Published online Dec 16, 2025. doi: 10.4253/wjge.v17.i12.112344
Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 gene: A case report and review of literature
Jun-Yao Wang, Yun Liu, Jun Xu, Fan Fan, Peng You, Tao Peng, Yu-Lan Liu, Ning Chen, Depart
Co-first authors: Jun-Yao Wang and Yun Liu.
Author contributions: Wang JY and Liu Y wrote the paper, and they are contributed equally to this manuscript and are co-first authors; Fan F, Peng T, and You P performed gastroduodenoscopy and colonoscopy; Peng T and You P performed enteroscopy; Chen N and Liu YL edited the paper.
Supported by the National Natural Science Foundation of China (General Program), No. 82000493; and Peking University People’s Hospital Scientific Research Development Funds, No. RDJP2023-09.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ning Chen, MD, Chief Physician, Department of Gastroenterology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. chenning79@bjmu.edu.cn
Received: July 25, 2025
Revised: September 30, 2025
Accepted: November 11, 2025
Published online: December 16, 2025
Processing time: 144 Days and 15.4 Hours
Revised: September 30, 2025
Accepted: November 11, 2025
Published online: December 16, 2025
Processing time: 144 Days and 15.4 Hours
Core Tip
Core Tip: We present a 33-year-old female patient who was admitted for anemia, edema, and a positive fecal occult blood test. She was diagnosed with chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 (SLCO2A1) due to heterozygous mutations, c.1658T>A (p.Ile553Asn) and c.940+1G>A (splice-5) in SLCO2A1, which had not been previously reported. Chronic enteropathy associated with SLCO2A1 should be considered in patients with anemia and edema to avoid inappropriate therapies.