Xu PW, Xu QQ, Yu Y, Jiao Y, Liu YH, Yang L. Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2026; 18(3): 115736 [DOI: 10.4253/wjge.v18.i3.115736]
Corresponding Author of This Article
Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130000, Jilin Province, China. yahui@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 16, 2026 (publication date) through Mar 18, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Endoscopy
ISSN
1948-5190
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Xu PW, Xu QQ, Yu Y, Jiao Y, Liu YH, Yang L. Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2026; 18(3): 115736 [DOI: 10.4253/wjge.v18.i3.115736]
World J Gastrointest Endosc. Mar 16, 2026; 18(3): 115736 Published online Mar 16, 2026. doi: 10.4253/wjge.v18.i3.115736
Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis
Pei-Wen Xu, Qian-Qian Xu, Yan Yu, Yan Jiao, Ya-Hui Liu, Lei Yang
Pei-Wen Xu, Lei Yang, Endoscopic Center, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Qian-Qian Xu, Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Yan Yu, Department of The First Operation Room, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Yan Jiao, Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Co-corresponding authors: Ya-Hui Liu and Lei Yang.
Author contributions: Liu YH, Xu PW and Yang L revised the manuscript; Xu PW and Yang L contributed critically to figure design, playing key roles in refining the scientific clarity and visual presentation of the review; Xu QQ contributed to the conceptualization, literature review, and initial drafting of the manuscript; Yu Y was responsible for data collection and provided important intellectual revisions; Jiao Y conceived and supervised the study; Liu YH and Yang L contributed equally to this manuscript and are co-corresponding authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130000, Jilin Province, China. yahui@jlu.edu.cn
Received: October 24, 2025 Revised: November 28, 2025 Accepted: January 20, 2026 Published online: March 16, 2026 Processing time: 140 Days and 20.8 Hours
Core Tip
Core Tip: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis remains the most frequent and severe complication of ERCP, arising from the interplay of patient and procedural risk factors. Key predictors include female sex, younger age, sphincter of Oddi dysfunction, difficult cannulation, and pancreatic duct manipulation. Evidence strongly supports rectal non-steroidal anti-inflammatory drugs, prophylactic pancreatic duct stenting, and aggressive intravenous hydration as effective preventive measures, particularly in high-risk patients. Recent advances in risk prediction models and artificial intelligence-driven analytics offer opportunities for individualized risk assessment and tailored prophylaxis, which may markedly reduce post-ERCP pancreatitis incidence and improve procedural safety.
