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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Feb 16, 2026; 18(2): 116000
Published online Feb 16, 2026. doi: 10.4253/wjge.v18.i2.116000
Published online Feb 16, 2026. doi: 10.4253/wjge.v18.i2.116000
Endoscopic clip systems for hemostasis and defect closure in gastrointestinal endoscopy
Enrik John T Aguila, Institute of Digestive and Liver Diseases, St. Luke’s Medical Center Global City, Taguig City 1634, Metro Manila, Philippines
Enrik John T Aguila, Endoscopy Unit, Ospital ng Maynila Medical Center, Manila 1004, Metro Manila, Philippines
Enrik John T Aguila, School of Medicine and Public Health, Ateneo de Manila University, Pasig City 1604, Metro Manila, Philippines
Louis H S Lau, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong 999077, China
Louis H S Lau, Institute of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong 999077, China
Louis H S Lau, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China
James Weiquan Li, Division of Medicine and Inpatient Care, Sengkang General Hospital, Singapore 544886, Singapore
Tyler M Berzin, Center for Advanced Endoscopy, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States
Author contributions: Aguila EJT, Lau LHS, Li JW, and Berzin TM reviewed the literature, provided the analysis, and drafted the manuscript; and all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Enrik John T Aguila, MD, Institute of Digestive and Liver Diseases, St. Luke’s Medical Center Global City, Rizal Drive cor. 32nd St. and 5th Ave., Taguig City 1634, Metro Manila, Philippines. enjtaguila@stlukes.com.ph
Received: October 31, 2025
Revised: November 20, 2025
Accepted: January 6, 2026
Published online: February 16, 2026
Processing time: 96 Days and 16 Hours
Revised: November 20, 2025
Accepted: January 6, 2026
Published online: February 16, 2026
Processing time: 96 Days and 16 Hours
Core Tip
Core Tip: Endoscopic clipping has evolved considerably, with modern through-the-scope clips and over-the-scope clips offering versatile, effective options for hemostasis and gastrointestinal defect closure. This article summarizes essential device features, comparative performance, and practical, evidence-based techniques for optimal clip selection and deployment. A clear understanding of clip anatomy, technical principles, and escalation thresholds is crucial for achieving durable closure, improving safety, and enhancing clinical outcomes.