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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jan 16, 2026; 18(1): 114791
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.114791
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.114791
Comparative outcomes of laparoscopic vs open pancreaticoduodenectomy in early-stage pancreatic cancer
Muhammad Kalim, Department of General Surgery, MTI Lady Reading Hospital, Peshawar 25000, Khyber Pakhtunkhwa, Pakistan
Marria Sarwar, Department of Surgery, Federal Medical and Dental College, Islamabad 44080, Pakistan
Syed Saad Ali Chishti, Department of Surgery, Beaumont Hospital, Dublin D09 V2N0, Ireland
Muharram Ali, Department of Surgery, Chandka Medical College Hospital, Bibi Aseefa Dental College, Larkana 77150, Sindh, Pakistan
Saqib Qayyum, Consultant General and Vascular Surgeon, Al-Khidmat Raazi Hospital, Rawalpindi 46000, Punjab, Pakistan
Jawad Ahmed, Department of General Surgery, Mayo Hospital, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Murk Memon, Department of General Surgery, Abbasi Shaheed Hospital, People’s University of Medical and Health Sciences, Karachi 75300, Sindh, Pakistan
Elham Shenawa, Department of Oncology, Balkh University, Balkh 1702, Afghanistan
Author contributions: Kalim M conceptualized the study, designed the methodology, and supervised data collection and surgical procedures; Sarwar M and Ahmed J contributed to data collection; Sarwar M contributed to literature review and drafting the introduction; Chishti SSA performed statistical analysis, including propensity score matching, and assisted in drafting the methods and results sections; Ali M contributed to data interpretation and critical revision of the manuscript for intellectual content; Qayyum S participated in surgical procedures and provided clinical expertise for protocol development; Ahmed J drafted the discussion section; Memon M contributed to data curation and manuscript revision; Shenawa E, coordinated the study, performed data analysis, drafted and revised the manuscript, and ensured compliance with ethical and journal guidelines. All authors reviewed and approved the final manuscript.
Institutional review board statement: The study protocol was reviewed and approved by the Institutional Review Board/Ethics Committee of MTI Lady Reading Hospital (Approval No. LRH/GEN-SURG/IRB/2025-047). The study adhered to the ethical standards of the institutional research committee and the principles of the Declaration of Helsinki.
Informed consent statement: Given the retrospective design of this study, the requirement for informed patient consent was waived by the Institutional Review Board of MTI Lady Reading Hospital.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Elham Shenawa, MD, Department of Oncology, Balkh University, Chuk Sancharki, Mazar-I-Sharif, Balkh 1702, Afghanistan. eshenawa@gmail.com
Received: September 28, 2025
Revised: October 11, 2025
Accepted: November 21, 2025
Published online: January 16, 2026
Processing time: 109 Days and 6.8 Hours
Revised: October 11, 2025
Accepted: November 21, 2025
Published online: January 16, 2026
Processing time: 109 Days and 6.8 Hours
Core Tip
Core Tip: Pancreaticoduodenectomy (PD) remains the cornerstone treatment for resectable pancreatic ductal adenocarcinoma, but its morbidity is substantial. Minimally invasive techniques, particularly laparoscopic PD (LPD), have emerged as alternatives to open surgery. However, evidence in early-stage pancreatic cancer is limited. In this propensity-matched analysis from a high-volume center, LPD demonstrated reduced blood loss (by 170 mL), fewer transfusions, and a shorter hospital stay (by 3 days), while showing comparable complication rates, R0 resection rates, lymph node yield, and survival outcomes to open PD. These findings suggest that LPD may be a safe and effective option in carefully selected early-stage patients, supporting its integration into surgical practice in experienced centers.