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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jan 16, 2026; 18(1): 113617
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.113617
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.113617
Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation
Alberto Tringali, Anna Caiazzo, Department of Digestive Endoscopy and Gastroenterology, Unità Locale di Sanità e Sociale 2, Conegliano Hospital, Conegliano 31015, Veneto, Italy
Author contributions: Tringali A and Caiazzo A wrote the manuscript; Tringali A designed the study and reviewed the manuscript; Caiazzo A created tables and figures. Both authors have approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alberto Tringali, MD, PhD, Assistant Professor, Chief, Honorary Research Fellow, Lecturer, Department of Digestive Endoscopy and Gastroenterology, Unità Locale di Sanità e Sociale 2, Conegliano Hospital, Via Brigata Bisagno, Conegliano 31015, Veneto, Italy. albtri10@gmail.com
Received: August 29, 2025
Revised: September 19, 2025
Accepted: November 24, 2025
Published online: January 16, 2026
Processing time: 138 Days and 19.4 Hours
Revised: September 19, 2025
Accepted: November 24, 2025
Published online: January 16, 2026
Processing time: 138 Days and 19.4 Hours
Core Tip
Core Tip: In recent years, endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA) has become a subject of great interest in Digestive Endoscopy as locoregional treatment for pancreatic neoplastic lesions, particularly for pancreatic neoplastic cysts, pancreatic functional and non-functional neuroendocrine neoplasms and pancreatic ductal adenocarcinoma. The EUS-RFA procedure can potentially ablate these lesions locally in a minimally invasive manner with a very good safety profile. Our focus was to highlight the role of EUS-RFA in the treatment of pancreatic neuroendocrine tumors, based on available evidence, and describe the current potential benefits and limitations of this approach.