BPG is committed to discovery and dissemination of knowledge
Observational Study
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jan 16, 2026; 18(1): 112943
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.112943
Low-volume bowel preparation provides safe and effective pan-enteric capsule endoscopy in suspected or established Crohn’s disease
Snir Livne, Nathaniel Aviv Cohen, Naomi Fliss-Isakov, Moshe Leshno, Nitsan Maharshak, Eva Niv, Liat Deutsch
Snir Livne, Nathaniel Aviv Cohen, Nitsan Maharshak, Eva Niv, Liat Deutsch, School of Medicine, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
Nathaniel Aviv Cohen, Naomi Fliss-Isakov, Nitsan Maharshak, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel
Naomi Fliss-Isakov, Department of Health Promotions, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
Moshe Leshno, The Coller School of Management, Tel Aviv University, Tel Aviv 6997801, Israel
Eva Niv, Department of Gastroenterology, Meuhedet Health Services, Hadera 38100, Haifa, Israel
Liat Deutsch, Clinical Nutrition and Capsule Endoscopy Service, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel
Author contributions: Livne S, Fliss-Isakov N, Leshno M, and Deutsch L designed the study; Livne S, Cohen NA, and Deutsch L performed the research and acquired the data; Livne S, Fliss-Isakov N, Leshno M, and Deutsch L analyzed and interpreted the data; Livne S and Deutsch L wrote the manuscript; Cohen NA, Fliss-Isakov N, Leshno M, Maharshak N, Niv E, and Deutsch L revised the article critically for important intellectual content. All authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Tel Aviv Sourasky Medical Center (No. 0407-21-TLV).
Informed consent statement: Informed consent for participating in the study was waived.
Conflict-of-interest statement: Niv E serves as a consultant for Medtronic; Deutsch L has received past consulting and lecturing fees from Medtronic; However, the company was not involved in any aspect of this study. All other authors (Livne S, Cohen NA, Fliss-Isakov N, Leshno M, and Maharshak N) declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Dataset available from the corresponding author at liatml@tlvmc.gov.il on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liat Deutsch, MD, Head, Clinical Nutrition and Capsule Endoscopy Service, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 6423906, Israel. liatml@tlvmc.gov.il
Received: August 11, 2025
Revised: October 7, 2025
Accepted: December 2, 2025
Published online: January 16, 2026
Processing time: 157 Days and 13.6 Hours
Core Tip

Core Tip: This study evaluates a novel low-volume, sulfate-free bowel preparation protocol for pan-enteric capsule endoscopy compared to the standard high-volume protocol. Despite the substantially lower volume, low-volume protocol (LVP) achieved comparable completion rates and adequate colonic cleansing. A pooled analysis across cohorts supports these findings and suggests improved colonic visualization with LVP over high-volume protocol. LVP may therefore represent a safe, effective, and potentially more patient-friendly alternative for pan-enteric capsule endoscopy preparation, particularly in the evaluation of Crohn’s disease.