Cryoballoon treatment of endoscopically unresectable duodenal adenomas

doi:10.4253/wjge.v18.i1.112759

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Jan 16, 2026 (publication date) through Jan 16, 2026

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Endosc. Jan 16, 2026; 18(1): 112759
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.112759

Cryoballoon treatment of endoscopically unresectable duodenal adenomas

Negar Modirian, Mike T Wei, Shai Friedland

Negar Modirian, School of Medicine, St. George School, True Blue BB1210, Grenada

Mike T Wei, Department of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA 94305, United States

Shai Friedland, Department of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94305, United States

Shai Friedland, Gastroenterology, Stanford University, Palo Alto, CA 94305, United States

Co-corresponding authors: Mike T Wei and Shai Friedland.

Author contributions: Modirian N, Wei MT, and Friedland S contributed to planning the study; Modirian N contributed to interpreting the data, drafting and editing manuscript; Wei MT and Friedland S contributed to data collection and final revision of manuscript; Wei MT and Friedland S contributed equally to this manuscript and are co-corresponding authors.

Institutional review board statement: This retrospective study was approved by the Ethics Committee of Stanford University Administrative Panel on Human Subjects in Medical Research.

Informed consent statement: Because of retrospective study signed informed consent form is not needed. However, Stanford University has given permission to conduct this study.

Conflict-of-interest statement: Wei MT is Consultant for Neptune Medical, AgilTx, Capsovision. Friedland S is Consultant for Intuitive Surgical and Capsovision.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Mike T Wei, Department of Gastroenterology and Hepatology, Stanford University Medical Center, 300 Pasteur Drive, Palo Alto, CA 94305, United States. mtwei@stanford.edu

Received: August 6, 2025
Revised: October 22, 2025
Accepted: November 17, 2025
Published online: January 16, 2026
Processing time: 162 Days and 23 Hours

Core Tip

Core Tip: Conventional procedures for treating fibrotic, recurring, or widespread duodenal adenomas, such as snare polypectomy and endoscopic mucosal resection, may have limitations. This multicenter retrospective study examines cryoballoon ablation as a novel treatment for such complex lesions. The findings suggest that cryoballoon therapy is a safe and potentially successful treatment for non-circumferential flat adenomas, particularly those complicated by past resections and fibrosis. However, its effectiveness may be restricted in large circumferential lesions.