Choday S, Alsheikh J, Vyas N. Timing of intervention: Assessing early vs late endoscopic and surgical interventions in acute cholangitis. World J Gastrointest Endosc 2026; 18(1): 110353 [DOI: 10.4253/wjge.v18.i1.110353]
Corresponding Author of This Article
Silpa Choday, MD, Department of Internal Medicine, Creighton University School of Medicine, 3110 N Central Avenue, Phoenix, AZ 85012, United States. ushilpa19@gmail.com
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Gastroenterology & Hepatology
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 16, 2026 (publication date) through Jan 15, 2026
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Publication Name
World Journal of Gastrointestinal Endoscopy
ISSN
1948-5190
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Choday S, Alsheikh J, Vyas N. Timing of intervention: Assessing early vs late endoscopic and surgical interventions in acute cholangitis. World J Gastrointest Endosc 2026; 18(1): 110353 [DOI: 10.4253/wjge.v18.i1.110353]
World J Gastrointest Endosc. Jan 16, 2026; 18(1): 110353 Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.110353
Timing of intervention: Assessing early vs late endoscopic and surgical interventions in acute cholangitis
Silpa Choday, Jad Alsheikh, Neil Vyas
Silpa Choday, Jad Alsheikh, Department of Internal Medicine, Creighton University School of Medicine, Phoenix, AZ 85012, United States
Neil Vyas, Department of Gastroenterology, Creighton University School of Medicine, Phoenix, AZ 85012, United States
Author contributions: Choday S collected articles, generated tables, wrote most of the sections, and was a major contributor to writing the manuscript; Alsheikh J gathered relevant articles and contributed to the discussion section of the manuscript; Vyas N reviewed the article and made necessary changes to the manuscript; all authors read and approved of the final manuscript.
Institutional review board statement: Hospitalization data were obtained from the Nationwide Readmissions Database (NRD) spanning the calendar years 2016-2021. As the NRD does not contain identifiable personal information, this study was classified as not involving human subjects and was therefore exempt from Institutional Review Board approval and no informed consent statement is required.
Informed consent statement: Hospitalization data were obtained from the Nationwide Readmissions Database (NRD) spanning the calendar years 2016-2021. As the NRD does not contain identifiable personal information, this study was classified as not involving human subjects and was therefore exempt from Institutional Review Board approval and no informed consent statement is required.
Conflict-of-interest statement: The author has no relevant financial or non-financial interests to disclose.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Silpa Choday, MD, Department of Internal Medicine, Creighton University School of Medicine, 3110 N Central Avenue, Phoenix, AZ 85012, United States. ushilpa19@gmail.com
Received: June 5, 2025 Revised: June 17, 2025 Accepted: November 17, 2025 Published online: January 16, 2026 Processing time: 224 Days and 16.3 Hours
Core Tip
Core Tip: Timely intervention for biliary issues is crucial, as urgent and early retrograde cholangiopancreatography (ERCP) procedures generally lead to shorter hospital stays and lower costs compared to delayed interventions. Patients undergoing late ERCP face increased risks of severe complications like septic shock and respiratory failure, and higher readmission rates. While laparoscopic common bile duct exploration (LCBDE) patients experienced higher rates of certain complications (respiratory failure, bile duct perforation), adjusted analyses showed no significant difference in 30-day readmissions between LCBDE and ERCP, although LCBDE typically incurred longer stays and higher costs. Factors like older age, higher comorbidities, and Medicaid coverage were associated with increased 30-day readmission risk. Ultimately, prompt management of biliary conditions significantly influences patient outcomes, with delays often leading to a higher burden of care.
