Sedation in endoscopy: Finding the balance between safety and efficacy

doi:10.4253/wjge.v17.i8.109695

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Aug 16, 2025 (publication date) through Aug 15, 2025

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Aug 16, 2025; 17(8): 109695
Published online Aug 16, 2025. doi: 10.4253/wjge.v17.i8.109695

Sedation in endoscopy: Finding the balance between safety and efficacy

Iyad A Issa, Remi Lakis, Taly Issa

Iyad A Issa, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Abu Dhabi 41475, United Arab Emirates

Remi Lakis, Department of Gastroenterology and Hepatology, Al Zahra University Hospital, Beirut 0000, Beyrouth, Lebanon

Taly Issa, Medical School, University of Nicosia, Nicosia 24005, Lefkosía, Cyprus

Author contributions: Issa IA designed the overall concept and outline of the manuscript; Lakis R and Issa T contributed to the discussion and design of the manuscript; Issa IA, Lakis R and Issa T contributed to the writing, and editing the manuscript, illustrations, and review of literature; all authors have read and approved the final manuscript.

Conflict-of-interest statement: The authors declare no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Iyad A Issa, MD, Consultant, Department of Gastroenterology and Hepatology, Harley Street Medical Center, No. A21 Villa, Marina Village, Abu Dhabi 41475, United Arab Emirates. iyadissa71@gmail.com

Received: May 19, 2025
Revised: June 8, 2025
Accepted: July 17, 2025
Published online: August 16, 2025
Processing time: 88 Days and 19.3 Hours

Core Tip

Core Tip: Optimizing sedation in gastrointestinal endoscopy requires a careful balance of efficacy and safety, tailored to individual patient needs and procedural demands. Recent insights suggest that midazolam as a standalone agent can achieve comparable patient satisfaction and safety profiles to the traditional midazolam-fentanyl combination, potentially reducing the risk of opioid-related complications.