Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Aug 16, 2025; 17(8): 109313
Published online Aug 16, 2025. doi: 10.4253/wjge.v17.i8.109313
Endoscopic treatment modalities for colonic diverticular bleeding: A systematic review with direct and network meta-analyses
Zahid Ijaz Tarar, Mustafa Gandhi, Faisal Inayat, Umer Farooq, Baltej Singh, Ahtshamullah Chaudhry, Aun Muhammad, Ahmad Zain, Faisal Kamal
Zahid Ijaz Tarar, Mustafa Gandhi, Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, United States
Faisal Inayat, Department of Internal Medicine, Allama Iqbal Medical College, Lahore, Punjab 54550, Pakistan
Umer Farooq, Division of Gastroenterology and Hepatology, St. Louis University, St. Louis, MO 63104, United States
Baltej Singh, Department of Internal Medicine, ChristianaCare Union Hospital, Elkton, MD 21921, United States
Ahtshamullah Chaudhry, Department of Internal Medicine, St. Dominic’s Hospital, Jackson, MS 39216, United States
Aun Muhammad, Department of Hospital Medicine, Christus Southeast Texas Hospital-St. Elizabeth, Beaumont, TX 77702, United States
Ahmad Zain, Department of Internal Medicine, UC Health Parkview Medical Center, Pueblo, CO 81003, United States
Faisal Kamal, Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA 19107, United States
Author contributions: Tarar ZI, Gandhi M, Inayat F, Farooq U concepted and designed the study, participated in the acquisition of data, interpretation of results, writing of the original draft, and critical revisions of the important intellectual content of the final manuscript; Singh B, Chaudhry A, Muhammad A, Zain A, contributed to the analysis and interpretation of results and drafting of the manuscript; Kamal F reviewed, revised, and improved the manuscript by suggesting pertinent modifications; all authors critically assessed, edited, and approved the final manuscript and are accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2020 Checklist, and the manuscript was prepared and revised according to the PRISMA 2020 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Faisal Inayat, MBBS, Senior Researcher, Department of Internal Medicine, Allama Iqbal Medical College, Allama Shabbir Ahmad Usmani Road, Faisal Town, Lahore, Punjab 54550, Pakistan. faisalinayat@hotmail.com
Received: May 7, 2025
Revised: June 6, 2025
Accepted: July 18, 2025
Published online: August 16, 2025
Processing time: 100 Days and 4.3 Hours
Core Tip

Core Tip: The comparative efficacy of different endoscopic treatments for colonic diverticular bleeding (CDB) remains under-researched. This network meta-analysis compares the clinical outcomes of CDB in patients treated with endoscopic clipping, banding, and detachable snare ligation. Our findings indicate the superiority of endoscopic detachable snare ligation over endoscopic clipping and banding in achieving initial hemostasis and reducing the rate of late rebleeding. Band ligation had the fewest early rebleeding events with the highest P-score calculated using the frequentist approach. Future studies with large sample sizes should explore CDB outcomes based on the bleeding site and the timing of intervention.