Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jul 16, 2025; 17(7): 108289
Published online Jul 16, 2025. doi: 10.4253/wjge.v17.i7.108289
Endoscopic resection for esophageal gastrointestinal stromal tumors: Balancing R0 resection and long-term outcomes
Shinichiro Kobayashi, Yuki Muta, Shunsuke Murakami, Kengo Kanetaka
Shinichiro Kobayashi, Yuki Muta, Shunsuke Murakami, Kengo Kanetaka, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
Co-first authors: Shinichiro Kobayashi and Yuki Muta.
Author contributions: Kobayashi S and Muta Y wrote the original draft and read and approved the final version of the manuscript; Murakami M participated in editing the manuscript; Kanetaka K participated in editing the manuscript and approved the final version.
Conflict-of-interest statement: The authors have no competing interests to declare.
Open Access: This is an open-access article selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, providing that the original work is properly cited and its use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shinichiro Kobayashi, Associate Professor, FACS, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan. skobayashi1980@gmail.com
Received: April 10, 2025
Revised: May 5, 2025
Accepted: June 9, 2025
Published online: July 16, 2025
Processing time: 90 Days and 19.2 Hours
Core Tip

Core Tip: Xu et al highlighted the potential of performing endoscopic resection (ER) for esophageal gastrointestinal stromal tumors (E-GISTs). However, the 75% R0 resection rate raises concerns. Although ER offers a minimally invasive access, recurrence after R0 resection underscores the need for careful patient selection. Future studies should refine ER techniques; identify optimal candidates based on tumor size, location, risk, and genetics; and develop algorithms for treatment selection. Long-term follow-up is essential for assessing recurrence and ultimately guiding evidence-based E-GIST management.