Kobayashi S, Muta Y, Murakami S, Kanetaka K. Endoscopic resection for esophageal gastrointestinal stromal tumors: Balancing R0 resection and long-term outcomes. World J Gastrointest Endosc 2025; 17(7): 108289 [DOI: 10.4253/wjge.v17.i7.108289]
Corresponding Author of This Article
Shinichiro Kobayashi, Associate Professor, FACS, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan. skobayashi1980@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shinichiro Kobayashi, Yuki Muta, Shunsuke Murakami, Kengo Kanetaka, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
Co-first authors: Shinichiro Kobayashi and Yuki Muta.
Author contributions: Kobayashi S and Muta Y wrote the original draft and read and approved the final version of the manuscript; Murakami M participated in editing the manuscript; Kanetaka K participated in editing the manuscript and approved the final version.
Conflict-of-interest statement: The authors have no competing interests to declare.
Open Access: This is an open-access article selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, providing that the original work is properly cited and its use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shinichiro Kobayashi, Associate Professor, FACS, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan. skobayashi1980@gmail.com
Received: April 10, 2025 Revised: May 5, 2025 Accepted: June 9, 2025 Published online: July 16, 2025 Processing time: 90 Days and 19.2 Hours
Abstract
Xu et al retrospectively assessed endoscopic resection (ER) for esophageal gastrointestinal stromal tumors (E-GISTs) and reported excellent 5-year survival rates. Although ER shows promise as a minimally invasive procedure, the 75% R0 resection rate with recurrence observed even after R0 resection warrants further discussion. We highlight the need for careful patient selection based on tumor size, location, and risk, considering endoscopic and thoracoscopic approaches. Future studies should refine ER techniques, optimize patient selection, and establish long-term follow-up to guide E-GIST management.
Core Tip: Xu et al highlighted the potential of performing endoscopic resection (ER) for esophageal gastrointestinal stromal tumors (E-GISTs). However, the 75% R0 resection rate raises concerns. Although ER offers a minimally invasive access, recurrence after R0 resection underscores the need for careful patient selection. Future studies should refine ER techniques; identify optimal candidates based on tumor size, location, risk, and genetics; and develop algorithms for treatment selection. Long-term follow-up is essential for assessing recurrence and ultimately guiding evidence-based E-GIST management.
