Bagrodia A, Vaithiyam V, Laguduva Mohan S. Large colorectal lesions: Expanding the boundaries of endoscopic management. World J Gastrointest Endosc 2025; 17(12): 115008 [DOI: 10.4253/wjge.v17.i12.115008]
Corresponding Author of This Article
Venkatesh Vaithiyam, DM, MD, Assistant Professor, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, 1, JLN Marg, Raj Ghat, New Delhi 110002, Delhi, India. venkateshvaithiyam172@gmail.com
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Gastroenterology & Hepatology
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 16, 2025 (publication date) through Dec 19, 2025
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World Journal of Gastrointestinal Endoscopy
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1948-5190
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Bagrodia A, Vaithiyam V, Laguduva Mohan S. Large colorectal lesions: Expanding the boundaries of endoscopic management. World J Gastrointest Endosc 2025; 17(12): 115008 [DOI: 10.4253/wjge.v17.i12.115008]
World J Gastrointest Endosc. Dec 16, 2025; 17(12): 115008 Published online Dec 16, 2025. doi: 10.4253/wjge.v17.i12.115008
Large colorectal lesions: Expanding the boundaries of endoscopic management
Amit Bagrodia, Venkatesh Vaithiyam, Supraja Laguduva Mohan
Amit Bagrodia, Venkatesh Vaithiyam, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India
Supraja Laguduva Mohan, Department of Radiology, All India Institute of Medical Sciences, New Delhi 110024, Delhi, India
Author contributions: Bagrodia A and Vaithiyam V contributed to this paper; Vaithiyam V designed the overall concept and outline of the manuscript; Bagrodia A contributed to the discussion and design of the manuscript; Vaithiyam V and Laguduva Mohan S contributed to the review and editing of the manuscript, illustrations, and literature review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Venkatesh Vaithiyam, DM, MD, Assistant Professor, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, 1, JLN Marg, Raj Ghat, New Delhi 110002, Delhi, India. venkateshvaithiyam172@gmail.com
Received: October 9, 2025 Revised: November 14, 2025 Accepted: December 3, 2025 Published online: December 16, 2025 Processing time: 72 Days and 13.5 Hours
Core Tip
Core Tip: Large colorectal lesions constitute a distinct group with increased potential for malignancy, and their removal is technically challenging for endoscopists. Endoscopic mucosal resection is fundamental for many benign lesions; however, the risk of recurrence necessitates complete resection of lesion margins. Endoscopic submucosal dissection provides higher en bloc rates with oncological safety, whereas endoscopic full-thickness resection is beneficial for non-lifting or fibrotic lesions within the device’s limits. Consolidated evidence, including that of Zhu et al, emphasizes that tumor size alone should not dictate surgery; careful patient selection, expertise, and structured surveillance can improve endoscopic outcomes while maintaining bowel continuity.
