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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2025; 17(11): 110207
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.110207
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.110207
Impact of gut microbiome on outcomes following endoscopic interventions in gastrointestinal disease
Himanshu Agrawal, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Delhi 110095, India
Nitin Agarwal, Nikhil Gupta, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India
Author contributions: Agrawal H took charge of drafting the manuscript; Agrawal H and Gupta N were responsible for the research conception and design; Agrawal H, Agarwal N, and Gupta N were jointly responsible for data acquisition, data analysis and interpretation, critical revision of the manuscript, supervision; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikhil Gupta, Professor, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Received: June 3, 2025
Revised: June 12, 2025
Accepted: September 23, 2025
Published online: November 16, 2025
Processing time: 167 Days and 0.9 Hours
Revised: June 12, 2025
Accepted: September 23, 2025
Published online: November 16, 2025
Processing time: 167 Days and 0.9 Hours
Core Tip
Core Tip: The gut microbiome critically influences patient outcomes after endoscopic procedures by modulating mucosal healing and inflammation. Disruptions from bowel preparation and the procedures affect microbial balance, with targeted probiotic and microbiome-based therapies offering promising recovery improvements. Integration of multi-omics and machine learning enables personalized prediction and management of complications, marking a shift toward precision medicine in gastrointestinal endoscopy.