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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2025; 17(10): 111408
Published online Oct 16, 2025. doi: 10.4253/wjge.v17.i10.111408
Published online Oct 16, 2025. doi: 10.4253/wjge.v17.i10.111408
Primary adenocarcinoma from a gastric heterotopic pancreas: A case report
Ya-Xin Wang, Department of Gastroenterology, Ordos Central Hospital, Ordos 017001, Inner Mongolia Autonomous Region, China
Jing Wang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Endoscopy Center, Peking University Cancer Hospital & Institute, Beijing 100142, China
Shi-Xiu Liang, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266000, Shandong Province, China
Qi Wu, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Endoscopy Center, Peking University Cancer Hospital & Institute, Beijing 100142, China
Co-corresponding authors: Ya-Xin Wang and Qi Wu.
Author contributions: Wang YX and Wang J wrote the manuscript and performed the literature search; Liang SX collected and processed the medical records and figures of the patient; Wu Q supervised the preparation of this case report and provided innovative research point. Wang YX and Wang J have contributed equally to this work and are equal contributors. All authors have read and approved the final manuscript.
Supported by Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing, No. HP2024-19-503002; and National Key R&D Program of China, No. 2023YFC2413802; Beijing Municipal Administration of Hospitals Incubating Program, No. PX2024041.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Xin Wang, Chief Physician, Department of Gastroenterology, Ordos Central Hospital, No. 6 Sudu Street, Ordos 017001, Inner Mongolia Autonomous Region, China. 369489315@qq.com
Received: July 1, 2025
Revised: July 24, 2025
Accepted: September 9, 2025
Published online: October 16, 2025
Processing time: 107 Days and 18.1 Hours
Revised: July 24, 2025
Accepted: September 9, 2025
Published online: October 16, 2025
Processing time: 107 Days and 18.1 Hours
Core Tip
Core Tip: We have described a case of adenocarcinoma arising from gastric heterotopic pancreas. If the cancer has invaded the mucosal layer, gastric endoscopy with biopsy has great utility for preoperative diagnosis. Alternatively, evaluation can be performed with endoscopic ultrasound, and with endoscopic ultrasound-guided fine needle aspiration if necessary. Tumor markers need to be regularly tested in the postoperative follow-up of such patients. Clinicians need to be mindful of the possibility of malignant transformation of heterotopic pancreas, especially with duodenal or gastric submucosal tumor-like lesions with obstructive symptoms.