Han SY, Papachristou GI, Shah RJ, Conwell DL. Effect of pancreatic endotherapy on quality of life in chronic pancreatitis patients: A systematic review. World J Gastrointest Endosc 2021; 13(8): 336-344 [PMID: 34512881 DOI: 10.4253/wjge.v13.i8.336]
Corresponding Author of This Article
Samuel Y Han, MD, MS, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave. 2nd Floor Doan Office Tower, Columbus, OH 43210, United States. samuel.han@osumc.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Aug 16, 2021; 13(8): 336-344 Published online Aug 16, 2021. doi: 10.4253/wjge.v13.i8.336
Effect of pancreatic endotherapy on quality of life in chronic pancreatitis patients: A systematic review
Samuel Y Han, Georgios I Papachristou, Raj J Shah, Darwin L Conwell
Samuel Y Han, Georgios I Papachristou, Darwin L Conwell, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Raj J Shah, Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States
Author contributions: Han SY and Conwell DL wrote the paper; Papachristou GI and Shah RJ reviewed and revised the paper.
Conflict-of-interest statement: Papachristou GI is a Consultant for Olympus, and has received research funding from AbbVie; Author Shah RJ is an Advisory Board Member and Consultant for Boston Scientific and Consultant for Olympus and Cook Endoscopy; Conwell DC received support from the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award number U01 DK108327.
PRISMA 2009 Checklist statement: This manuscript was presented in accordance with the PRISMA guidelines for a systematic review.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Samuel Y Han, MD, MS, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave. 2nd Floor Doan Office Tower, Columbus, OH 43210, United States. samuel.han@osumc.edu
Received: February 12, 2021 Peer-review started: February 12, 2021 First decision: May 5, 2021 Revised: June 11, 2021 Accepted: July 13, 2021 Article in press: July 13, 2021 Published online: August 16, 2021 Processing time: 180 Days and 14.5 Hours
ARTICLE HIGHLIGHTS
Research background
While pancreatic endotherapy is frequently performed for the treatment of chronic pancreatitis-related complications, most studies examining endotherapy have focused on technical success outcomes, such as stricture resolution or stone clearance. Studies reporting patient-centered outcomes such as quality of life are lacking, however, making it difficult to determine how endotherapy affects these patients.
Research motivation
The motivation for this systematic review stems from the primary criticism of pancreatic endotherapy on whether endotherapy improves the lives of patients with chronic pancreatitis. While it is well-known that endotherapy can treat the structural complications of chronic pancreatitis, the effect of endotherapy on patient-centered outcomes is poorly studied.
Research objectives
The primary objective of this systematic review was to detail the literature regarding how pancreatic endotherapy affects quality of life in chronic pancreatiits patients.
Research methods
A systematic review was performed to identify studies reporting on various pancreatic endotherapy modalities and quality of life.
Research results
The search yielded 13 studies for review out of 10242 articles. All of the modalities examined found an improvement in quality of life.
Research conclusions
Pancreatic endotherapy does appear to improve quality of life, but the assessment of quality of life is very heterogeneous and not disease-specific. Furthermore, there is a lack of evidence regarding many modalities such as transmural fluid drainage, pancreatoscopy-guided therapy and celiac plexus block.
Research perspectives
Further studies are clearly needed to elucidate the patient experience with receiving pancreatic endotherapy and future trials will benefit from having patient-centered outcomes as the primary outcome.
