Mukundan A, Gupta D, Karmakar R, Wang HC. Endoscopic resection: A novel approach for treating oesophageal gastrointestinal stromal tumours. World J Gastrointest Endosc 2025; 17(6): 107088 [DOI: 10.4253/wjge.v17.i6.107088]
Corresponding Author of This Article
Hsiang-Chen Wang, Professor, Department of Mechanical Engineering, National Chung Cheng University, Graduate Institute of Opto-Mechatronics, Chiayi 62102, Taiwan. hcwang@ccu.edu.tw
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Jun 16, 2025; 17(6): 107088 Published online Jun 16, 2025. doi: 10.4253/wjge.v17.i6.107088
Endoscopic resection: A novel approach for treating oesophageal gastrointestinal stromal tumours
Arvind Mukundan, Devansh Gupta, Riya Karmakar, Hsiang-Chen Wang
Arvind Mukundan, Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nādu, India
Arvind Mukundan, Department of Mechanical Engineering, Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Chiayi 621, Taiwan
Devansh Gupta, Department of Computer Science and Engineering, Thapar Institute of Engineering and Technology, Patiala 147001, Punjab, India
Riya Karmakar, Hsiang-Chen Wang, Department of Mechanical Engineering, National Chung Cheng University, Chiayi 62102, Taiwan
Co-first authors: Arvind Mukundan and Devansh Gupta.
Co-corresponding authors: Hsiang-Chen Wang and Riya Karmakar.
Author contributions: Mukundan A and Wang HC performed formal analysis, acquired the funding for this research, conducted project administration, and provided resources; Karmakar R and Gupta D carried out investigation; Mukundan A, Gupta D, and Karmakar R developed the methodology; Gupta D wrote the original draft; Gupta D and Karmakar R were responsible for software; Wang HC supervised the research; Mukundan A, Gupta D, Karmakar R and Wang HC conceptualized and designed the research, performed data curation, and performed writing-review and editing; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hsiang-Chen Wang, Professor, Department of Mechanical Engineering, National Chung Cheng University, Graduate Institute of Opto-Mechatronics, Chiayi 62102, Taiwan. hcwang@ccu.edu.tw
Received: March 16, 2025 Revised: April 18, 2025 Accepted: April 28, 2025 Published online: June 16, 2025 Processing time: 88 Days and 15.6 Hours
Abstract
In this letter, a commentary on the article by Xu et al has been provided. Gastrointestinal stomal tumours (GISTs) are rare tumours that originate commonly in stomach (60%-70%) and small intestine (30%-40%). The course of treatment especially oesophageal GIST is very complex and hard to diagnose because of limited availability of pathological and clinical data. Endoscopic resection (ER) is a minimally invasive approach for removing tumours from the oesophagus and digestive system that does not require open surgery and is especially successful for very small and low-risk GIST. A retrospective examination of 32 patients treated with ER between 2012 and 2023 was conducted to analyse clinical and pathological characteristics, effectiveness of therapy, and long-term prognosis. The findings demonstrate en bloc resection was achieved in 96.9% of cases with an R0 resection rate of 75% with a median size of tumour was approximately 2.12 cm. Post-surgery complication like hydrothorax, post-endoscopic submucosal dissection electrocoagulation syndrome occurred in about 25% of cases which later go resolved by conservative treatment. Recurrence of GIST was approximately 9.4% primarily in high-risk cases. ER should be widely adopted in clinical practise preferably for managing low-risk oesophageal GIST because of its high success rate, low recurrence rates and excellent survival results, ensuring better patient prognosis.
Core Tip: Gastrointestinal stomal tumours (GISTs) are safely and effectively treated by the endoscopic resection (ER) in the esophagus. It has a small camera to remove the tumour through small cuts. This makes the recovery process relatively easy for the patients. In fact, the best results were seen in smaller and low-risk tumours, with most showing good results. Nevertheless, there might be some complications: (1) The collection of fluid or some minor pain after the treatment; and (2) These usually get treated without the need for further surgery. ER is thus recommended for the management of low-risk esophageal GIST since there are fewer problems and better recovery thereafter.
