Lanke G, Ali FS, Lee JH. Clinical update on the management of pseudopapillary tumor of pancreas. World J Gastrointest Endosc 2018; 10(9): 145-155 [PMID: 30283597 DOI: 10.4253/wjge.v10.i9.145]
Corresponding Author of This Article
Jeffrey H Lee, MD, Professor, Department of Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States. jefflee@mdanderson.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Sep 16, 2018; 10(9): 145-155 Published online Sep 16, 2018. doi: 10.4253/wjge.v10.i9.145
Clinical update on the management of pseudopapillary tumor of pancreas
Gandhi Lanke, Faisal S Ali, Jeffrey H Lee
Gandhi Lanke, Faisal S Ali, Jeffrey H Lee, Department of Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Author contributions: Lanke G composed and drafted the paper; Ali SF provided the figures and edited the paper; Lee JH provided outlines, reviewed and edited the paper.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jeffrey H Lee, MD, Professor, Department of Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States. jefflee@mdanderson.org
Telephone: +1-713-7945073 Fax: +1-713-5634408
Received: March 14, 2018 Peer-review started: March 14, 2018 First decision: April 23, 2018 Revised: April 28, 2018 Accepted: June 8, 2018 Article in press: June 9, 2018 Published online: September 16, 2018 Processing time: 187 Days and 2.5 Hours
Abstract
Solid pseudopapillary neoplasm (SPN) is a rare tumor with malignant potential which is generally located in the tail of pancreas. The prevalence of SPN has increased with widespread use of cross sectional imaging. SPN is often misdiagnosed due to nonspecific clinical presentation and accurate diagnosis is essential for optimal management. Endoscopic ultrasound-FNA with immunohistochemistry can help in preoperative diagnosis. Surgery is the treatment of choice and a successful R0 resection is curative. Overall, SPN has a good prognosis. This review article focuses on pathogenesis, diagnosis and management of SPN.
Core tip: Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that predominantly affects young females. SPNs are usually indolent but they do have malignant potential. The pathogenesis of SPN is not entirely clear. Accurate diagnosis is essential in the management of SPN. Endoscopic ultrasound guided fine needle aspiration with immunohistochemistry can help distinguish SPNs from other aggressive pancreatic tumors preoperatively. Surgical resection with clear margins is curative and should be offered whenever feasible. The prognosis of SPN is good even in the presence of metastasis.
