Cholongitas E, Pipili C, Papatheodoridis GV. Interferon-free regimens in patients with hepatitis C infection and renal dysfunction or kidney transplantation. World J Hepatol 2017; 9(4): 180-190 [PMID: 28217256 DOI: 10.4254/wjh.v9.i4.180]
Corresponding Author of This Article
Evangelos Cholongitas, Assistant Professor of Internal Medicine, 4th Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, 49, Konstantinopoleos Street, 54642 Thessaloniki, Greece. cholongitas@yahoo.gr
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Gastroenterology & Hepatology
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Minireviews
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Table 4 Recommended regimens from the American Association for the Study of Liver Diseases and European Association for the Study of the Liver for patients with chronic hepatitis C and severe renal impairment (glomerular filtration rate < 30 mL/min) who need urgent hepatitis C virus therapy and renal transplantation is not an immediate option
Elbasvir/grazoprevir for 12 wk (for 1a or 1b) or ombitasvir/paritaprevir/ritonavir plus dasabuvir1 (for 1b) for 12 wk
Elbasvir/grazoprevir or ombitasvir/paritaprevir plus dasabuvir (for 1a or 1b), for 12 wk (plus RBV 200 mg/d for 1a if the haemoglobin level is > 10 g/dL at baseline)
2, 3, 5 or 6
Pegylated interferon-alfa plus dose-adjusted ribavirin (200 mg daily)2
Sofosbuvir/velpatasvir or sofosbuvir plus daclatasvir (plus ribavirin if the haemoglobin level is > 10 g/dL at baseline for genotype 3) for 12 wk (or for 24 wk without ribavirin for genotype 3)4
4
Elbasvir/grazoprevir for 12 wk
Elbasvir/grazoprevir for 12 wk or ombitasvir/paritaprevir plus dasabuvir plus ribavirin (if the haemoglobin level is > 10 g/dL at baseline) for 12 wk
Citation: Cholongitas E, Pipili C, Papatheodoridis GV. Interferon-free regimens in patients with hepatitis C infection and renal dysfunction or kidney transplantation. World J Hepatol 2017; 9(4): 180-190