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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 8, 2017; 9(4): 180-190
Published online Feb 8, 2017. doi: 10.4254/wjh.v9.i4.180
Published online Feb 8, 2017. doi: 10.4254/wjh.v9.i4.180
Interferon-free regimens in patients with hepatitis C infection and renal dysfunction or kidney transplantation
Evangelos Cholongitas, 4th Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, 54642 Thessaloniki, Greece
Chrysoula Pipili, Division of Nephrology, Queen Elizabeth University Hospital, Glasgow G51 4TF, United Kingdom
George V Papatheodoridis, Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece
Author contributions: Cholongitas E and Pipili C performed the literature search, wrote the first draft of the manuscript and approved the final version; Papatheodoridis GV wrote and edited the final draft of the manuscript and approved the final version.
Conflict-of-interest statement: Cholongitas E: Advisor/consultant/sponsored lectures for Abbvie, Astellas, Bristol-Myers Squibb, Gilead, Merck Sharp and Dohme, Novartis; Pipili C: None; Papatheodoridis GV: Grant/research support from Abbvie, Bristol-Myers Squibb, Gilead, Janssen, Roche; advisor/consultant for Abbvie, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead, GlaxoSmithKleine, Janssen, Merck Sharp and Dohme, Novartis, Roche; sponsored lectures for Abbvie, Bristol-Myers Squibb, Gilead, GlaxoSmithKline, Janssen, Merck Sharp and Dohme, Novartis, Roche; Data Safety Management Board for Gilead.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Evangelos Cholongitas, Assistant Professor of Internal Medicine, 4th Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, 49, Konstantinopoleos Street, 54642 Thessaloniki, Greece. cholongitas@yahoo.gr
Telephone: +30-23-10892110 Fax: +30-23-10855566
Received: September 14, 2016
Peer-review started: September 18, 2016
First decision: October 21, 2016
Revised: November 21, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 8, 2017
Processing time: 145 Days and 7 Hours
Peer-review started: September 18, 2016
First decision: October 21, 2016
Revised: November 21, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 8, 2017
Processing time: 145 Days and 7 Hours
Core Tip
Core tip: Recent evidence showed very good safety and efficacy of both interferon and ribavirin-free direct acting antivirals (DAAs) regimens in patients with severe kidney disease (CKD) or kidney transplantation. Nevertheless, sofosbuvir, the backbone of most antiviral schemes is officially contraindicated in patients with CKD (creatinine clearance < 30 mL/min). Accordingly, CKD patients with genotype 1 or 4 can be currently treated with available ribavirin free DAAs regimens without sofosbuvir, while those with non-1, non-4 genotype can officially be treated with peginterferon with or without ribavirin, but they are actually treated with sofosbuvir-based regimens mostly if they have advanced liver disease.